Juliane Cabral Silva: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Raimundo Gonçalves de Oliveira Júnior: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Mariana Gama e Silva: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Érica Martins de Lavor: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Juliana Mikaelly Dias Soares: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Sarah Raquel Gomes de Lima-Saraiva: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Tâmara Coimbra Diniz: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Rosemairy Luciane Mendes: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Edilson Beserra de Alencar Filho: Role: InvestigationRole: MethodologyRole: Writing – original draftRole: Writing –
review & editing
Eliezer Jesus de Lacerda Barreiro: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: Writing – original draftRole: Writing –
review & editing
Lídia Moreira Lima: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: Writing – original draftRole: Writing –
review & editing
Jackson Roberto Guedes da Silva Almeida:
ORCID: http://orcid.org/0000-0002-0867-1357
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Gautam Sethi: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
30
July
2018
Publication date Collection: 2018
Volume: 13
Issue: 7
Electronic Location Identifier: e0199009
Affiliations
[1
]
Núcleo de Estudos e Pesquisas de Plantas Medicinais (NEPLAME), Universidade Federal
do Vale do São Francisco, Petrolina, Brasil
[2
]
Colegiado de Farmácia, Universidade Federal do Vale do São Francisco, Petrolina, Brasil
[3
]
Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos (INCT-INOFAR),
Universidade Federal do Rio de Janeiro, Laboratório de Avaliação e Síntese de Substâncias
Bioativas (LASSBio), Rio de Janeiro, Brasil
National University Singapore Yong Loo Lin School of Medicine, SINGAPORE
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Jackson Roberto Guedes da Silva Almeida
http://orcid.org/0000-0002-0867-1357
Article
Publisher ID:
PONE-D-17-37387
DOI: 10.1371/journal.pone.0199009
PMC ID: 6066216
PubMed ID: 30059558
SO-VID: 703ccafa-f071-423a-833e-a8e80b7984d1
Copyright © © 2018 Silva et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/501100003593, Conselho Nacional de Desenvolvimento Científico e Tecnológico;
Award ID: 465249/2014-0
Award Recipient
:
Eliezer Jesus de Lacerda Barreiro
The authors received specific funding of Conselho Nacional de Desenvolvimento Científico
e Tecnológico (Process CNPq 465249/2014-0), INCT-INOFAR (Instituto Nacional de Ciência
e Tecnologia de Fármacos e Medicamentos) for this work. The project is coordinated
by Prof. Eliezer Jesus de Lacerda Barreiro. The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Edema
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Edema
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Ears
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Ears
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Neurochemistry
Subject:
Neurotransmitters
Subject:
Biogenic Amines
Subject:
Histamine
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Neurochemistry
Subject:
Neurotransmitters
Subject:
Biogenic Amines
Subject:
Histamine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Histamine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Histamine
Subject:
Medicine and health sciences
Subject:
Pharmacology
Subject:
Drugs
Subject:
Analgesics
Subject:
NSAIDs
Subject:
Medicine and health sciences
Subject:
Pain management
Subject:
Analgesics
Subject:
NSAIDs
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Sensory Perception
Subject:
Nociception
Subject:
Biology and Life Sciences
Subject:
Psychology
Subject:
Sensory Perception
Subject:
Nociception
Subject:
Social Sciences
Subject:
Psychology
Subject:
Sensory Perception
Subject:
Nociception
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Lipids
Subject:
Prostaglandins
