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      Cataract induction by administration of nitroglycerin in cardiac patients through imbalance in redox status

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          Abstract

          Purpose

          The objective of this study was to evaluate the role of nitroglycerin in the pathogenesis of cataract.

          Design

          Prospective study.

          Patient and methods

          This study was performed in adults from tertiary Saudi Arabian hospitals (34 males and 26 females in each group, aged from 40 to 60 years), who were divided into four groups with an equal number of subjects (control group, cardiac group, idiopathic cataract group, and a group of cardiac patients using nitroglycerin and with cataracts). Fasting glucose concentrations, blood glycated hemoglobin levels, lipid profiles, and levels of nitrite, conjugated dienes (CD), thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and reduced glutathione (GSH) were determined.

          Results

          Treatment of cardiac patients with nitroglycerin produced an imbalance in their systemic redox status, leading to the development of cataracts, which was reflected by a significant increase in the levels of nitrite, CD, and TBARS and a significant decrease in SOD activity and GSH, compared with idiopathic cataract patients. The results of correlation studies and multiple regression analysis revealed a significant positive correlation between different biochemical parameters (GSH, SOD, TBARS, CD, and nitrite) in the blood and lens in both idiopathic cataract patients and cardiac patients treated with nitroglycerin.

          Conclusion

          The study points to the relative and predictive effects of nitric oxide derived from nitroglycerin in the development of cataract in the presence of the oxidative stress induced by nitroglycerin treatment.

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          Most cited references 35

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          Microsomal lipid peroxidation.

           S Aust,  J A Buege (1977)
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            Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.

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              A modified spectrophotometric assay of superoxide dismutase.

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                Author and article information

                Journal
                Ther Clin Risk Manag
                Ther Clin Risk Manag
                Therapeutics and Clinical Risk Management
                Therapeutics and Clinical Risk Management
                Dove Medical Press
                1176-6336
                1178-203X
                2016
                27 September 2016
                : 12
                : 1487-1496
                Affiliations
                [1 ]Pharmacology and Toxicology Department, College of Pharmacy, Qassim University, Buraydah, Kingdom of Saudi Arabia
                [2 ]Pharmacology and Toxicology Department, College of Pharmacy, Tanta University, Tanta
                [3 ]Hormone Department, National Research Center, Giza, Egypt
                [4 ]Pharmacy Services Department, Security Forces Hospital, Riyadh, Kingdom of Saudi Arabia
                Author notes
                Correspondence: Rehab M El-Gharabawy, Pharmacology and Toxicology Department, College of Pharmacy, Tanta University, El-bahr St, 33347, Tanta, Egypt, Tel +20 40 9665 4234 1840, Email drrehab200932@ 123456yahoo.com
                Article
                tcrm-12-1487
                10.2147/TCRM.S114469
                5045900
                27729797
                © 2016 El-Gharabawy et al. This work is published and licensed by Dove Medical Press Limited

                The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                Categories
                Original Research

                Medicine

                lens, nitroglycerin, oxidative stress, cataract, nitrite

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