Human chorionic gonadotropin stimulation gives evidence of differences in testicular steroidogenesis in Klinefelter syndrome, as assessed by liquid chromatography-tandem mass spectrometry.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Men with Klinefelter syndrome (KS) show hypergonadotropic hypogonadism, but the pathogenesis of hypotestosteronemia remains unclear. Testicular steroidogenesis in KS men was evaluated over three decades ago after human chorionic gonadotropin (hCG) stimulation, but inconclusive results were obtained. Intriguingly, some recent studies show increased intratesticular testosterone concentrations in men with KS.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Eur. J. Endocrinol.

Title: European journal of endocrinology

Publisher: BioScientifica

ISSN (Electronic): 1479-683X

ISSN (Print): 0804-4643

Publication date (Electronic): Jun 2016

Volume: 174

Issue: 6

Affiliations

[1 ] Unit of EndocrinologyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

[2 ] Unit of EndocrinologyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy Department of MedicineEndocrinology, Metabolism and Geriatrics, Azienda USL of Modena, Modena, Italy santi.daniele@gmail.com.

[3 ] Unit of EndocrinologyDepartment of Medical and Surgical Sciences, Centre for Applied Biomedical Research, Unit S. Orsola-Malpighi Hospital, Alma Mater University of Bologna, Bologna, Italy.

[4 ] Department of Laboratory Medicine and Pathological AnatomyAzienda USL of Modena, Modena, Italy.

[5 ] Department of MedicineEndocrinology, Metabolism and Geriatrics, Azienda USL of Modena, Modena, Italy.

[6 ] Unit of EndocrinologyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy Department of MedicineEndocrinology, Metabolism and Geriatrics, Azienda USL of Modena, Modena, Italy.

[7 ] Unit of EndocrinologyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy Department of MedicineEndocrinology, Metabolism and Geriatrics, Azienda USL of Modena, Modena, Italy Center for Genomic ResearchUniversity of Modena and Reggio Emilia, Modena, Italy.

Article

Publisher Item ID: 174/6/801

DOI: 10.1530/EJE-15-1224

PubMed ID: 27188454

SO-VID: 704c491e-96ca-46a1-b88f-51d342f7cce4

History

Data availability:

Comments

Comment on this article

scite_

Cited by 5

See all cited by