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      A Cost Effectiveness Analysis of Salt Reduction Policies to Reduce Coronary Heart Disease in Four Eastern Mediterranean Countries

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          Abstract

          Background

          Coronary Heart Disease (CHD) is rising in middle income countries. Population based strategies to reduce specific CHD risk factors have an important role to play in reducing overall CHD mortality. Reducing dietary salt consumption is a potentially cost-effective way to reduce CHD events. This paper presents an economic evaluation of population based salt reduction policies in Tunisia, Syria, Palestine and Turkey.

          Methods and Findings

          Three policies to reduce dietary salt intake were evaluated: a health promotion campaign, labelling of food packaging and mandatory reformulation of salt content in processed food. These were evaluated separately and in combination. Estimates of the effectiveness of salt reduction on blood pressure were based on a literature review. The reduction in mortality was estimated using the IMPACT CHD model specific to that country. Cumulative population health effects were quantified as life years gained (LYG) over a 10 year time frame. The costs of each policy were estimated using evidence from comparable policies and expert opinion including public sector costs and costs to the food industry. Health care costs associated with CHDs were estimated using standardized unit costs. The total cost of implementing each policy was compared against the current baseline (no policy). All costs were calculated using 2010 PPP exchange rates. In all four countries most policies were cost saving compared with the baseline. The combination of all three policies (reducing salt consumption by 30%) resulted in estimated cost savings of $235,000,000 and 6455 LYG in Tunisia; $39,000,000 and 31674 LYG in Syria; $6,000,000 and 2682 LYG in Palestine and $1,3000,000,000 and 378439 LYG in Turkey.

          Conclusion

          Decreasing dietary salt intake will reduce coronary heart disease deaths in the four countries. A comprehensive strategy of health education and food industry actions to label and reduce salt content would save both money and lives.

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          Most cited references18

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          Chronic disease prevention: health effects and financial costs of strategies to reduce salt intake and control tobacco use.

          In 2005, WHO set a global goal to reduce rates of death from chronic (non-communicable) disease by an additional 2% every year. To this end, we investigated how many deaths could potentially be averted over 10 years by implementation of selected population-based interventions, and calculated the financial costs of their implementation. We selected two interventions: to reduce salt intake in the population by 15% and to implement four key elements of the WHO Framework Convention on Tobacco Control (FCTC). We used methods from the WHO Comparative Risk Assessment project to estimate shifts in the distribution of risk factors associated with salt intake and tobacco use, and to model the effects on chronic disease mortality for 23 countries that account for 80% of chronic disease burden in the developing world. We showed that, over 10 years (2006-2015), 13.8 million deaths could be averted by implementation of these interventions, at a cost of less than US$0.40 per person per year in low-income and lower middle-income countries, and US$0.50-1.00 per person per year in upper middle-income countries (as of 2005). These two population-based intervention strategies could therefore substantially reduce mortality from chronic diseases, and make a major (and affordable) contribution towards achievement of the global goal to prevent and control chronic diseases.
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            Effectiveness and costs of interventions to lower systolic blood pressure and cholesterol: a global and regional analysis on reduction of cardiovascular-disease risk.

            Cardiovascular disease accounts for much morbidity and mortality in developed countries and is becoming increasingly important in less developed regions. Systolic blood pressure above 115 mm Hg accounts for two-thirds of strokes and almost half of ischaemic heart disease cases, and cholesterol concentrations exceeding 3.8 mmol/L for 18% and 55%, respectively. We report estimates of the population health effects, and costs of selected interventions to reduce the risks associated with high cholesterol concentrations and blood pressure in areas of the world with differing epidemiological profiles. Effect sizes were derived from systematic reviews or meta-analyses, and the effect on health outcomes projected over time for populations with differing age, sex, and epidemiological profiles. Incidence data from estimates of burden of disease were used in a four-state longitudinal population model to calculate disability-adjusted life years (DALYs) averted and patients treated. Costs were taken from previous publications, or estimated by local experts, in 14 regions. Non-personal health interventions, including government action to stimulate a reduction in the salt content of processed foods, are cost-effective ways to limit cardiovascular disease and could avert over 21 million DALYs per year worldwide. Combination treatment for people whose risk of a cardiovascular event over the next 10 years is above 35% is also cost effective leading to substantial additional health benefits by averting an additional 63 million DALYs per year worldwide. The combination of personal and non-personal health interventions evaluated here could lower the global incidence of cardiovascular events by as much as 50%.
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              Cost-effectiveness of interventions to reduce dietary salt intake.

              To evaluate population health benefits and cost-effectiveness of interventions for reducing salt in the diet. Proportional multistate life-table modelling of cardiovascular disease and health sector cost outcomes over the lifetime of the Australian population in 2003. The current Australian programme of incentives to the food industry for moderate reduction of salt in processed foods; a government mandate of moderate salt limits in processed foods; dietary advice for everyone at increased risk of cardiovascular disease and dietary advice for those at high risk. Costs measured in Australian dollars for the year 2003. Health outcomes measured in disability-adjusted life years (DALY) averted over the lifetime. Mandatory and voluntary reductions in the salt content of processed food are cost-saving interventions under all modelled scenarios of discounting, costing and cardiovascular disease risk reversal (dominant cost-effectiveness ratios). Dietary advice targeting individuals is not cost-effective under any of the modelled scenarios, even if directed at those with highest blood pressure risk only (best case median cost-effectiveness A$100 000/DALY; 95% uncertainty interval A$64 000/DALY to A$180 000/DALY). Although the current programme that relies on voluntary action by the food industry is cost-effective, the population health benefits could be 20 times greater with government legislation on moderate salt limits in processed foods. Programmes to encourage the food industry to reduce salt in processed foods are highly recommended for improving population health and reducing health sector spending in the long term, but regulatory action from government may be needed to achieve the potential of significant improvements in population health.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, USA )
                1932-6203
                2014
                7 January 2014
                : 9
                : 1
                : e84445
                Affiliations
                [1 ]Yunus Centre for Social Business and Health, Glasgow Caledonian University, Glasgow, United Kingdom
                [2 ]Institute of Community and Public Health, Birzeit University, Birzeit, Palestine, Occupied Palestinian territory
                [3 ]Department of Public Health and Policy, Institute of Psychology, Health and Society, University of Liverpool, Liverpool, United Kingdom
                [4 ]Department of Health Economics, Ministry of Health, Nablus, Palestine, Occupied Palestinian territory
                [5 ]Dokuz Eylül University Faculty of Medicine, Department of Public Health, İnciraltı- İzmir, Turkiye
                [6 ]Narlidere Community Health Center, Provincial Health Directorate of Izmir, Izmir, Turkey
                [7 ]INTES/University of Carthage, Tunis, Tunisia
                [8 ]Cardiovascular Disease Epidemiology and Prevention Research Laboratory, Faculty of Medicine, University Tunis El Manar, Tunis, Tunisia
                [9 ]Syrian Center for Tobacco Studies, Aleppo, Syria
                [10 ]Public Health Program, Department of Health Sciences, Qatar University, Doha, Qatar
                Groningen Research Institute of Pharmacy, Netherlands
                Author notes

                ¶ Membership of the MedCHAMPS project team is provided in the Acknowledgments.

                Competing Interests: The authors have declared that no competing interests exist.

                Conceived and designed the experiments: HM AS RG MOF SC RK AH. Performed the experiments: HM AS RG MOF SC RK SJ BU KS CA WA HBR RAA FF AH. Analyzed the data: HM AS RG MOF SC RK AH. Contributed reagents/materials/analysis tools: HM AS RG MOF SC RK SJ BU KS CA WA HBR RAA FF AH. Wrote the paper: HM AS RG MOF SC RK SJ BU KS CA WA HBR RAA FF AH.

                Article
                PONE-D-13-22225
                10.1371/journal.pone.0084445
                3883693
                24409297
                704ec1ff-914f-40c1-a5ad-8e6c0946b4ac
                Copyright @ 2014

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 22 May 2013
                : 15 November 2013
                Page count
                Pages: 10
                Funding
                The research leading to these results has received funding from the European Community' Seventh Framework Programme (FP7/2007–2013) under grant agreement n°223075 – the MedCHAMPS project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Medicine
                Cardiovascular
                Coronary Artery Disease
                Clinical Research Design
                Modeling
                Epidemiology
                Cardiovascular Disease Epidemiology
                Global Health
                Non-Clinical Medicine
                Health Care Policy
                Health Education and Awareness
                Health Risk Analysis
                Health Economics
                Cost Effectiveness
                Nutrition
                Public Health
                Preventive Medicine
                Social and Behavioral Sciences
                Economics
                Health Economics
                Cost Effectiveness
                Cost-Effectiveness Analysis
                Operations Research
                Policy Models
                Economic Models
                Political Science
                Political Aspects of Health
                Public Policy

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                Uncategorized

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