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      Glial inhibition of CNS axon regeneration.

      1 ,
      Nature reviews. Neuroscience
      Springer Science and Business Media LLC

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          Abstract

          Damage to the adult CNS often leads to persistent deficits due to the inability of mature axons to regenerate after injury. Mounting evidence suggests that the glial environment of the adult CNS, which includes inhibitory molecules in CNS myelin as well as proteoglycans associated with astroglial scarring, might present a major hurdle for successful axon regeneration. Here, we evaluate the molecular basis of these inhibitory influences and their contributions to the limitation of long-distance axon repair and other types of structural plasticity. Greater insight into glial inhibition is crucial for developing therapies to promote functional recovery after neural injury.

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          Author and article information

          Journal
          Nat Rev Neurosci
          Nature reviews. Neuroscience
          Springer Science and Business Media LLC
          1471-003X
          1471-003X
          Aug 2006
          : 7
          : 8
          Affiliations
          [1 ] Division of Neuroscience, Children's Hospital, Boston, Massachusetts 02115, USA.
          Article
          nrn1956 NIHMS87532
          10.1038/nrn1956
          2693386
          16858390
          70556340-b36e-4786-b174-3f6bc3e04f02
          History

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