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Normothermic ex vivo lung perfusion in clinical lung transplantation.
Marcelo Cypel
1 ,
Jonathan C Yeung ,
Mingyao Liu ,
Masaki Anraku ,
Fengshi Chen ,
Wojtek Karolak ,
Masaaki Sato ,
Jane Laratta ,
Sassan Azad ,
Mindy Madonik ,
Chung-Wai Chow ,
Cecilia Chaparro ,
Michael Hutcheon ,
Lianne G Singer ,
Arthur S Slutsky ,
Kazuhiro Yasufuku ,
Marc de Perrot ,
Andrew F Pierre ,
Thomas K Waddell ,
Shaf Keshavjee
Apr 14 2011
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Abstract
More than 80% of donor lungs are potentially injured and therefore not considered suitable for transplantation. With the use of normothermic ex vivo lung perfusion (EVLP), the retrieved donor lung can be perfused in an ex vivo circuit, providing an opportunity to reassess its function before transplantation. In this study, we examined the feasibility of transplanting high-risk donor lungs that have undergone EVLP.