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      Catechin ameliorates depressive symptoms in Sprague Dawley rats subjected to chronic unpredictable mild stress by decreasing oxidative stress

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          Abstract

          Catechin is an active ingredient of green tea. It is reported to inhibit corticosteroid-induced anxiety and depression-like symptoms. Considering the complex nature of depression, effects of catechin need to be studied in a clinically relevant depression model. The present study was designed to explore the antidepressant effect of catechin in Sprague Dawley rats subjected to chronic unpredictable mild stress (CUMS). Animals were subjected to CUMS and treated with (+)-catechin (50 mg/kg) or escitalopram (10 mg/kg) orally; a CUMS control and a vehicle control that was not exposed to CUMS were also established. Various stressors were applied daily in an unpredictable manner for 8 weeks achieve CUMS. Sucrose preference test were performed after 4 and 8 weeks and forced swim tests (FSTs) were conducted at weeks 4, 6 and 8. At the end of week 8, animals were sacrificed and the brain homogenate was studied for antioxidant parameters. Compared with the vehicle control, animals of the CUMS control group showed a significant decrease in sucrose intake. Catechin and escitalopram treatment significantly improved the sucrose intake compared with the CUMS control. A similar trend was observed in the FSTs, where catechin and escitalopram treatment significantly reduced the immobility time, and antioxidant parameters, including catalase, glutathione and superoxide dismutase levels were recovered in treated animals compared with the CUMS control. Thus, it was concluded that catechin reverses CUMS-induced depression in rats by ameliorating oxidative stress, which may help to develop a novel treatment for major depressive disorder.

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          Author and article information

          Journal
          Biomed Rep
          Biomed Rep
          BR
          Biomedical Reports
          D.A. Spandidos
          2049-9434
          2049-9442
          August 2019
          24 June 2019
          24 June 2019
          : 11
          : 2
          : 79-84
          Affiliations
          [1 ]Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
          [2 ]Ecron Acunova Ltd., Manipal, Karnataka 576104, India
          [3 ]Department of Anatomy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
          Author notes
          Correspondence to: Dr Nitesh Kumar, Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, Karnataka 576104, India nitesh.kumar@ 123456manipal.edu

          *Contributed equally

          Article
          PMC6610213 PMC6610213 6610213 BR-0-0-1226
          10.3892/br.2019.1226
          6610213
          31338194
          7066ecb2-97f5-4e50-ad86-6bcfea253f2c
          Copyright © 2019, Spandidos Publications
          History
          : 08 March 2019
          : 10 June 2019
          Categories
          Articles

          sucrose preference test,chronic unpredictable mild stress model,catechin,forced swim test

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