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      Time-Course of the Effect of α-Methyl-p-Tyrosine on ACTH Secretion

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          Abstract

          250 mg/kg i.p. of the methyl ester of α-methyl-p-tyrosine ( α-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by α-MpT.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1975
          1975
          20 March 2008
          : 18
          : 3
          : 272-276
          Affiliations
          Department of Pharmacology and Endocrinology, IInd Faculty of Medicine, University of Naples, Naples, and Service d’Endocrinologie, Hopital de la Conception, Marseille
          Article
          122406 Neuroendocrinology 1975;18:272–276
          10.1159/000122406
          171597
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Short Communications

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