Time-Course of the Effect of  α -Methyl-p-Tyrosine on ACTH Secretion

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Abstract

250 mg/kg i.p. of the methyl ester of α-methyl-p-tyrosine ( α-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by α-MpT.

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Author and article information

Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1975

Publication date (Print): 1975

Publication date (Electronic): 20 March 2008

Volume: 18

Issue: 3

Pages: 272-276

Affiliations

Department of Pharmacology and Endocrinology, IInd Faculty of Medicine, University of Naples, Naples, and Service d’Endocrinologie, Hopital de la Conception, Marseille

Article

Publisher ID: 122406 Other ID: Neuroendocrinology 1975;18:272–276

DOI: 10.1159/000122406

PubMed ID: 171597

SO-VID: 7068189b-fe0d-4ef8-a92c-299dd993d239

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 31 January 1975

Date accepted : 23 June 1975

Page count

Pages: 5

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Time-Course of the Effect of α-Methyl-p-Tyrosine on ACTH Secretion

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