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      Effect of L-Dopa on Plasma TSH Levels in Primary Hypothyroidism

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          Abstract

          Plasma TSH responses after an i.v. injection of 100 mg of L-dopa were evaluated by radioimmunoassay in 4 normal euthyroid subjects and in 8 patients with primary hypothyroidism. In agreement with previous results, no variations in plasma TSH levels were observed in the euthyroid subjects. In contrast, in primary hypothyroidism L-dopa induced a biphasic response in plasma TSH. In fact, we observed a transitory increase with a maximum at 30 min (mean ± SEM = 54 ± 18%) followed by a decrease reaching a minimum level of plasma TSH basal values at 90 min (mean ± SEM = 15 ± 6%). These findings demonstrate that the plasma TSH response to L-dopa in primary hypothyroidism is time-dependent. Some speculation on the possible mechanism of this action is presented.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1975
          1975
          20 March 2008
          : 17
          : 2
          : 147-153
          Affiliations
          Divisions of Endocrinology, I and II School of Medicine, and Department of Pharmacology, II School of Medicine, University of Naples, Naples
          Article
          122350 Neuroendocrinology 1975;17:147–153
          10.1159/000122350
          1134620
          © 1975 S. Karger AG, Basel

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          Pages: 7
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