Calcium β-Hydroxy-β-Methylbutyrate

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Abstract

The binding capacity of calcium β-hydroxy-β-methylbutyrate (calcium HMB), compared to other binders, was investigated in an in vitro study. Fifty milli-equivalents of either calcium HMB, calcium acetate, calcium carbonate, aluminum hydroxide gel or non-gel aluminum hydroxide was added to a phosphate solution, titrated (HC1 or NaOH), shaken and centrifuged to four different pH levels at 37 °C (simulating the gastrointestinal milieu). The difference in phosphate concentration between that of the initial and that of the supernatant represented from the bound phosphate in the precipitate. After 4 h at a pH of 6 (representing the intestinal condition after a meal), the binding percentage was: calcium acetate = 95.6%, calcium HMB = 92.6%, calcium carbonate = 46.4%, aluminum hydroxide gel = 33.4% and non-gel aluminum hydroxide = 17.8%. There was no significant difference (p > 0.05) between calcium HMB and calcium acetate. These results suggest that calcium HMB is an efficient phosphate binder in vitro, which may predict its effective role in vivo.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1996

Publication date (Print): 1996

Publication date (Electronic): 18 December 2008

Volume: 72

Issue: 3

Pages: 391-394

Affiliations

^aDepartment of Medicine, Nephrology Division, Evangelic School of Medicine, Curitiba, Brazil; ^bDepartment of Surgery, State University of New York, Stony Brook, N.Y., and ^cDepartment of Animal Sciences, Iowa State University, Ames, Iowa, USA

Article

Publisher ID: 188901 Other ID: Nephron 1996;72:391–394

DOI: 10.1159/000188901

PubMed ID: 8852485

SO-VID: 707d49c7-49fb-44d5-a5e3-d04dbec128ee

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 17 February 1995

Page count

Pages: 4

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