For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
29
views
96
references
 Top references
cited by
21
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
2 collections
    0
    shares
      284
      similar
       All similar

      The APC waiver has been extended to also apply to manuscripts submitted until March 31, 2024.

      To submit to the journal, please click here.

      • Record: found
      • Abstract: found
      • Article: found

      Adenovirus-triggered innate signalling pathways

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Adenoviruses are important infectious agents and also emerging vectors in different biomedical applications. These viruses elicit a strong innate and adaptive immune response, which influences both the course of disease and the success of the applied vectors. Several Toll-like Receptor (TLR)-dependent and -independent mechanisms contribute to these responses. Understanding of the involved viral and cellular factors is crucial for the treatment of various adenovirus diseases and the optimal design of adenovirus vector applications. Here we summarize our current understanding of the complex nature of adenovirus-induced innate immune mechanisms.

          Related collections

          Most cited references96

          • Record: found
          • Abstract: found
          • Article: not found

          Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.

          J M Bergelson, J. A. Cunningham, G Droguett … (1997)
          A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR). When transfected with CAR complementary DNA, nonpermissive hamster cells became susceptible to coxsackie B virus attachment and infection. Furthermore, consistent with previous studies demonstrating that adenovirus infection depends on attachment of a viral fiber to the target cell, CAR-transfected hamster cells bound adenovirus in a fiber-dependent fashion and showed a 100-fold increase in susceptibility to virus-mediated gene transfer. Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
          Article 0 comments Cited 505 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.

            E. Kurt-Jones, L. Popova, L Kwinn … (2000)
            The innate immune system contributes to the earliest phase of the host defense against foreign organisms and has both soluble and cellular pattern recognition receptors for microbial products. Two important members of this receptor group, CD14 and the Toll-like receptor (TLR) pattern recognition receptors, are essential for the innate immune response to components of Gram-negative and Gram-positive bacteria, mycobacteria, spirochetes and yeast. We now find that these receptors function in an antiviral response as well. The innate immune response to the fusion protein of an important respiratory pathogen of humans, respiratory syncytial virus (RSV), was mediated by TLR4 and CD14. RSV persisted longer in the lungs of infected TLR4-deficient mice compared to normal mice. Thus, a common receptor activation pathway can initiate innate immune responses to both bacterial and viral pathogens.
            Article 0 comments Cited 359 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              CD46 is a cellular receptor for group B adenoviruses.

              Anuj Gaggar, Dmitry Shayakhmetov, Andre Lieber (2003)
              Group B adenoviruses, a subgenus of human Adenoviridae, are associated with a variety of often-fatal illnesses in immunocompromised individuals, including bone marrow transplant recipients and cancer and AIDS patients. Recently, group B adenovirus derivatives have gained interest as attractive gene therapy vectors because they can transduce target tissues, such as hematopoietic stem cells, dendritic cells and malignant tumor cells, that are refractory to infection by commonly used adenoviral vectors. Whereas many adenoviruses infect cells through the coxsackievirus and adenovirus receptor (CAR), group B adenoviruses use an alternate, as-yet-unidentified cellular attachment receptor. Using mass spectrometric analysis of proteins interacting with a group B fiber, we identified human CD46 as a cellular attachment receptor for most group B adenoviruses. We show that ectopic expression of human CD46 rendered nonhuman cells susceptible to infection with group B viruses in vitro and in vivo. In addition, both siRNA-mediated knockdown of CD46 and a soluble form of CD46 blocked infection of human cell lines and primary human cells. The discovery that group B adenoviruses use CD46, a ubiquitously expressed complement regulatory protein, as a cellular attachment receptor elucidates the diverse clinical manifestation of group B virus infections, and bears directly on the application of these vectors for gene therapy.
              Article 0 comments Cited 168 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (publisher-id): 1886
                Journal ID (MPID): 122234
                Title: European Journal of Microbiology and Immunology
                Abbreviated Title: EuJMI
                Publisher: Akadémiai Kiadó, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V.
                ISSN (Print): 2062-509X
                ISSN (Electronic): 2062-8633
                Publication date (Print): 1 December 2011
                Volume: 1
                Issue: 4
                Pages: 279-288
                Affiliations
                [ 1 ] Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
                [ 2 ] Peninsula College of Medicine and Dentistry, Plymouth, Truro, UK
                [ 3 ] Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
                [ 4 ] Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108, Freiburg, Germany
                Author notes
                [* ] +49-761-5108 412, +49-761-5108 403, fejer@ 123456immunbio.mpg.de
                Article
                Other ID: 3
                DOI: 10.1556/eujmi.1.2011.4.3
                PMC ID: 3918130
                PubMed ID: 24516734
                SO-VID: 7098f756-6789-4aab-ad20-f5dcb3b9e01a
                History
                Date received : 11 October 2011
                Date accepted : 15 October 2011

                ScienceOpen disciplines: Medicine,Immunology,Health & Social care,Microbiology & Virology,Infectious disease & Microbiology
                Keywords: viral entry,IRF7,adenovirus,IL-1,type-I interferons,Toll-like receptors,innate response,endosomal escape
                Data availability:
                ScienceOpen disciplines: Medicine, Immunology, Health & Social care, Microbiology & Virology, Infectious disease & Microbiology
                Keywords: viral entry, IRF7, adenovirus, IL-1, type-I interferons, Toll-like receptors, innate response, endosomal escape

                Comments

                Comment on this article

                scite_

                Similar content284

                See all similar

                Cited by21

                See all cited by

                Most referenced authors821

                See all reference authors