Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

Inflammation in atherosclerosis.

Nature

pathology, immunology, Tunica Intima, Risk, Leukocytes, therapy, complications, Inflammation, Humans, Disease Susceptibility, Chemotaxis, Leukocyte, etiology, Arteriosclerosis, Animals

Read this article at

ScienceOpenPublisherPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Abundant data link hypercholesterolaemia to atherogenesis. However, only recently have we appreciated that inflammatory mechanisms couple dyslipidaemia to atheroma formation. Leukocyte recruitment and expression of pro-inflammatory cytokines characterize early atherogenesis, and malfunction of inflammatory mediators mutes atheroma formation in mice. Moreover, inflammatory pathways promote thrombosis, a late and dreaded complication of atherosclerosis responsible for myocardial infarctions and most strokes. The new appreciation of the role of inflammation in atherosclerosis provides a mechanistic framework for understanding the clinical benefits of lipid-lowering therapies. Identifying the triggers for inflammation and unravelling the details of inflammatory pathways may eventually furnish new therapeutic targets.

      Related collections

      Author and article information

      Journal
      10.1038/nature01323
      12490960

      Comments

      Comment on this article