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      Myc's broad reach.

      1 ,
      Genes & development
      Cold Spring Harbor Laboratory

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          Abstract

          The role of the myc gene family in the biology of normal and cancer cells has been intensively studied since the early 1980s. myc genes, responding to diverse external and internal signals, express transcription factors (c-, N-, and L-Myc) that heterodimerize with Max, bind DNA, and modulate expression of a specific set of target genes. Over the last few years, expression profiling, genomic binding studies, and genetic analyses in mammals and Drosophila have led to an expanded view of Myc function. This review is focused on two major aspects of Myc: the nature of the genes and pathways that are targeted by Myc, and the role of Myc in stem cell and cancer biology.

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          Author and article information

          Journal
          Genes Dev
          Genes & development
          Cold Spring Harbor Laboratory
          0890-9369
          0890-9369
          Oct 15 2008
          : 22
          : 20
          Affiliations
          [1 ] Institute of Molecular Biology and Tumor Research, 35033 Marburg, Germany.
          Article
          22/20/2755
          10.1101/gad.1712408
          2751281
          18923074
          70c40646-b5ea-4e6d-8e94-bf3e29d332fc
          History

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