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      Geometric Triangular Chiral Hexagon Crystal-Like Complexes Organization in Pathological Tissues Biological Collision Order

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      PLoS ONE
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          Abstract

          The present study describes and documents self-assembly of geometric triangular chiral hexagon crystal like complex organizations (GTCHC) in human pathological tissues.The authors have found this architectural geometric expression at macroscopic and microscopic levels mainly in cancer processes. This study is based essentially on macroscopic and histopathologic analyses of 3000 surgical specimens: 2600 inflammatory lesions and 400 malignant tumours. Geometric complexes identified photographically at macroscopic level were located in the gross surgical specimen, and these areas were carefully dissected. Samples were taken to carry out histologic analysis. Based on the hypothesis of a collision genesis mechanism and because it is difficult to carry out an appropriate methodological observation in biological systems, the authors designed a model base on other dynamic systems to obtain indirect information in which a strong white flash wave light discharge, generated by an electronic device, hits over the lines of electrical conductance structured in helicoidal pattern. In their experimental model, the authors were able to reproduce and to predict polarity, chirality, helicoid geometry, triangular and hexagonal clusters through electromagnetic sequential collisions. They determined that similar events among constituents of extracelular matrix which drive and produce piezoelectric activity are responsible for the genesis of GTCHC complexes in pathological tissues. This research suggests that molecular crystals represented by triangular chiral hexagons derived from a collision-attraction event against collagen type I fibrils emerge at microscopic and macroscopic scales presenting a lateral assembly of each side of hypertrophy helicoid fibers, that represent energy flow in cooperative hierarchically chiral electromagnetic interaction in pathological tissues and arises as a geometry of the equilibrium in perturbed biological systems. Further interdisciplinary studies must be carried out to reproduce, manipulate and amplify their activity and probably use them as a base to develop new therapeutic strategies in cancer.

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          Most cited references21

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          Piezoelectricity as a fundamental property of biological tissues.

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            Quasi-hexagonal molecular packing in collagen fibrils.

            Collagen molecules in native 66.8 nm (D) periodic fibrils are widely believed to be assembled into discrete, rope-like substructures, or microfibrils. Several types of microfibril have been proposed (2, 4, 5, 7- and 8-stranded) mainly on the basis of information contained in the medium angle X-ray diffraction patterns of native tendon fibres. These patterns show a series of equatorial and near-equatorial Bragg reflections which indicate that the collagen molecules are arranged on a three-dimensional crystalline lattice. The 4-stranded, 5-stranded and 8-stranded microfibrils are D-periodic with approximate diameter 3.8 nm, and these and the 2-stranded model are supposed to be packed on a three-dimensional lattice whose basal unit cell, (approximately) perpendicular to the fibril axis, is tetragonal (or quasi-tetragonal)with side a, a square root 2 or 2a, where a is approximately 3.8 nm. In this paper we describe a re-interpretation of the X-ray data which leads to a new model for the crystalline regions of the fibril, based on quasi-hexagonal molecular packing without microfibrillar sub-structures, and hence having the character of a molecular crystal.
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              Determining the chirality of Yukawa couplings via single charged Higgs boson production in polarized photon collisions.

              When the charged Higgs boson is too heavy to be produced in pairs, the predominant production mechanism at linear colliders is via the single charged Higgs boson production processes, such as e(-)e(+)-->bcH+,taunuH+ and gammagamma-->bcH+,taunuH+. We show that the yield of a heavy charged Higgs boson at a gammagamma collider is typically 1 or 2 orders of magnitude larger than that at an e(-)e(+) collider. Furthermore, a polarized gammagamma collider can determine the chirality of the Yukawa couplings of fermions with charged Higgs boson via single charged Higgs boson production and, thus, discriminate models of new physics.
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                Author and article information

                Contributors
                Role: Academic Editor
                Journal
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, USA )
                1932-6203
                2007
                12 December 2007
                : 2
                : 12
                : e1282
                Affiliations
                [1]Laboratory of Pathology, Department of Pathology, Clinic Health Social Entity Policarpa Salavarrieta, University Cooperativa of Colombia, Medicine School, Villavicencio, Meta, Colombia
                University of Freiburg, Germany
                Author notes
                * To whom correspondence should be addressed. E-mail: jaditod@ 123456hotmail.com

                Conceived and designed the experiments: JD NJ MM. Performed the experiments: JD NJ MM. Analyzed the data: JD NJ MM. Contributed reagents/materials/analysis tools: JD NJ. Wrote the paper: JD NJ MM.

                Article
                06-PONE-RA-00456R3
                10.1371/journal.pone.0001282
                2100170
                18074008
                70ccd24a-b2da-41c6-8f76-d14b524e2a35
                Diaz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
                History
                : 9 December 2006
                : 9 November 2007
                Page count
                Pages: 10
                Categories
                Research Article
                Biochemistry/Macromolecular Assemblies and Machines
                Biochemistry/Macromolecular Chemistry
                Cell Biology/Cytoskeleton
                Cell Biology/Morphogenesis and Cell Biology
                Pathology/Histopathology
                Pathology/Pathophysiology

                Uncategorized
                Uncategorized

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