7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Cell proliferation in carcinogenesis.

      Science (New York, N.Y.)

      2-Acetylaminofluorene, metabolism, toxicity, Animals, Carcinogens, pharmacology, Cell Division, drug effects, Humans, Liver, Liver Neoplasms, chemically induced, Mice, Mitotic Index, Rats, Saccharin, Urinary Bladder Neoplasms

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Chemicals that induce cancer at high doses in animal bioassays often fail to fit the traditional characterization of genotoxins. Many of these nongenotoxic compounds (such as sodium saccharin) have in common the property that they increase cell proliferation in the target organ. A biologically based, computerized description of carcinogenesis was used to show that the increase in cell proliferation can account for the carcinogenicity of nongenotoxic compounds. The carcinogenic dose-response relationship for genotoxic chemicals (such as 2-acetylaminofluorene) was also due in part to increased cell proliferation. Mechanistic information is required for determination of the existence of a threshold for the proliferative (and carcinogenic) response of nongenotoxic chemicals and the estimation of risk for human exposure.

          Related collections

          Author and article information

          Journal
          2204108

          Comments

          Comment on this article