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      Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages

      review-article
      1 , 2 , , 3 , 4 , 5 , 6 , 7 , 1 , 8 , 9 , 10 , 11 , 12 , 7 , 13 , 14 , 3 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27
      (Collab), (Collab), (Collab), (Collab), (Collab), (Collab), (Collab), (Collab), (Collab), (Collab), (Collab), (Collab), (Collab), (Collab)
      Blood
      American Society of Hematology

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          Abstract

          Publisher's Note: There is an [Related article:]Inside Blood Commentary on this article in this issue.

          Abstract

          The histiocytoses are rare disorders characterized by the accumulation of macrophage, dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults. More than 100 different subtypes have been described, with a wide range of clinical manifestations, presentations, and histologies. Since the first classification in 1987, a number of new findings regarding the cellular origins, molecular pathology, and clinical features of histiocytic disorders have been identified. We propose herein a revision of the classification of histiocytoses based on histology, phenotype, molecular alterations, and clinical and imaging characteristics. This revised classification system consists of 5 groups of diseases: (1) Langerhans-related, (2) cutaneous and mucocutaneous, and (3) malignant histiocytoses as well as (4) Rosai-Dorfman disease and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Herein, we provide guidelines and recommendations for diagnoses of these disorders.

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          Author and article information

          Journal
          Blood
          Blood
          bloodjournal
          blood
          Blood
          Blood
          American Society of Hematology (Washington, DC )
          0006-4971
          1528-0020
          2 June 2016
          10 March 2016
          2 June 2017
          : 127
          : 22
          : 2672-2681
          Affiliations
          [1 ]Research Unit EA4340, Versailles University, Paris-Saclay University, Boulogne, France;
          [2 ]Pathology Department, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Boulogne, France;
          [3 ]Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;
          [4 ]Pathology Department, Necker Hospital, Paris, France;
          [5 ]Department of Women’s and Children’s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden;
          [6 ]Department of Internal Medicine and French Reference Center for Rare Auto-immune and Systemic Diseases, Institut E3M, AP-HP, Pitié-Salpêtrière Hospital, Paris, France;
          [7 ]Université Pierre et Marie Curie University Paris 6, Paris, France;
          [8 ]Pediatric Hematology, Trousseau Hospital, APHP, Paris, France;
          [9 ]Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain;
          [10 ]Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH;
          [11 ]Leukemia Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY;
          [12 ]Feigin Center, Texas Children’s Cancer Center, Houston, TX;
          [13 ]Pathology Department, Pitié-Salpétrière Hospital, Paris, France;
          [14 ]Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY;
          [15 ]Necker Enfants Malades Hospital, AP-HP, Paris, France;
          [16 ]Institut Imagine, Sorbonne Paris Cité, Université Paris Descartes, Paris, France;
          [17 ]Division of Clínical Immunology, Hospital General Universitario and Health Research Institute “Gregorio Marañón,” Madrid, Spain;
          [18 ]Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden;
          [19 ]Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, TX;
          [20 ]Mount Sinai School of Medicine, New York, NY;
          [21 ]Pathology Department, University of Pittsburgh School of Medicine, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA;
          [22 ]Dana-Farber Cancer Institute, Boston, MA;
          [23 ]Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;
          [24 ]Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA;
          [25 ]Division of Pulmonary, Saint Louis Hospital, Paris, France;
          [26 ]Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN; and
          [27 ]Clarient Pathology Services, Aliso Viejo, CA
          Author information
          http://orcid.org/0000-0002-6073-4466
          Article
          PMC5161007 PMC5161007 5161007 2016/690636
          10.1182/blood-2016-01-690636
          5161007
          26966089
          70d56038-5382-4045-a7ca-19dde62eb063
          © 2016 by The American Society of Hematology
          History
          : 12 January 2016
          : 02 March 2016
          Page count
          Pages: 10
          Categories
          5
          29
          8
          33
          100
          Review Article
          Custom metadata
          free

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