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      No Association between Mitochondrial DNA Copy Number and Colorectal Adenomas

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          Abstract

          Despite previously reported associations between peripheral blood mtDNA copy number and colorectal cancer, it remains unclear whether altered mtDNA copy number in peripheral blood is a risk factor for colorectal cancer or a biomarker for undiagnosed colorectal cancer. Though colorectal adenomas are well-recognized precursor lesions to colorectal cancer, no study has evaluated an association between mtDNA copy number and colorectal adenoma risk. Hence, we investigated an association between peripheral blood mtDNA copy number and incident, sporadic colorectal adenoma in 412 colorectal adenoma cases and 526 cancer-free controls pooled from three colonoscopy based case-control studies that used identical methods for case ascertainment, risk factor determination, and biospecimen collection. We also evaluated associations between relative mtDNA copy number and markers of oxidative stress, including circulating F 2-isoprostanes, carotenoids, and fluorescent oxidation products. We measured mtDNA copy number using a quantitative real time polymerase chain reaction (PCR). We used unconditional logistic regression to analyze the association between mtDNA copy number and colorectal adenoma risk after multivariable adjustment. We found no association between logarithmically transformed relative mtDNA copy number, analyzed as a continuous variable, and colorectal adenoma risk [odds ratio = 1.02, 95% CI: 0.82 – 1.27; p=0.86[. There were no statistically significant associations between relative mtDNA copy number and other markers of oxidative stress. Our findings, taken together with those from previous studies, suggest that relative mtDNA copy number in peripheral blood may more likely be a marker of early colorectal cancer than of risk for the disease or of in vivo oxidative stress.

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          Author and article information

          Journal
          8811105
          1399
          Mol Carcinog
          Mol. Carcinog.
          Molecular carcinogenesis
          0899-1987
          1098-2744
          10 May 2017
          10 August 2015
          August 2016
          01 August 2017
          : 55
          : 8
          : 1290-1296
          Affiliations
          [1 ]Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN
          [2 ]Department of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN
          [3 ]Department of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, GA
          Author notes
          [4 ]Corresponding author: Dr. Bharat Thyagarajan, University of Minnesota, Department of Laboratory Medicine and Pathology, 515, Delaware Street SE, Room 1-136 Moos Tower, Minneapolis, MN 55455. Telephone Number: (612) 624-1257, thya0003@ 123456umn.edu
          Article
          PMC5535736 PMC5535736 5535736 nihpa873277
          10.1002/mc.22370
          5535736
          26258394
          70ffd681-b508-4bb9-8321-855c1b8e9a26
          History
          Categories
          Article

          Mitochondrial DNA,Colorectal Adenoma,Oxidative Stress

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