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Low-dose bisphenol A disrupts gonad development and steroidogenic genes expression in adult female rare minnow Gobiocypris rarus.

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      Abstract

      Bisphenol A (BPA), an estrogenic monomer, has attracted many researchers to study its adverse effects in animal reproduction, especially in fish. To explore the effects of low dose BPA on adult female rare minnow Gobiocypris rarus, we exposed the fish to BPA at nominal concentrations of 5, 15, and 50 μg L(-1) for 14 and 35 d. The 35-d BPA exposure at 50 μg L(-1) had obviously suppressive effects on oocyte development, and BPA at all the three concentrations in both exposure durations of 14 and 35 d had stimulative effects on hepatic vitellogenin (vtg) transcription. BPA at lower concentrations (5 and 15 μg L(-1)) exhibited stimulative effects on the expressions of ovarian steroidogenic genes while at higher concentration (50 μg L(-1)) displayed inhibitive effects. Analysis of ovarian steroidogenic genes 5'-flanking regions and mRNA expressions of their potential regulatory factors revealed that the BPA-mediated actions on steroidogenesis in G. rarus ovary probably involve estrogen receptor (Esr) and androgen receptor (Ar) signaling, nuclear receptor subfamily 5, group A, number 1 (Nr5a1) pathway, and epigenetic regulation.

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      Affiliations
      [1 ] College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China.
      [2 ] College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China. Electronic address: zzwang@nwsuaf.edu.cn.
      Journal
      Chemosphere
      Chemosphere
      1879-1298
      0045-6535
      Oct 2014
      : 112
      25048937
      S0045-6535(14)00601-8
      10.1016/j.chemosphere.2014.04.089
      Copyright © 2014 Elsevier Ltd. All rights reserved.

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