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      Tetracycline: Release from Hydrophilic Gel Contact Lens and Intraocular Penetration

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          Application of tritiated tetracycline by means of hydrophilic gel contact lenses in rabbits revealed that about 20% of the antibiotic was released from the gel during a contact time of 5 h. Abrasion of the epithelium increased the intraocular penetration considerably. No accumulation of tetracycline in the eye tissues was observed even after 72 h of continuous application of contact lenses presoaked in tetracycline. Compared with the instillation of tetracycline solution, the application of contact lenses presoaked in tetracycline is much more effective with respect to the achieved level of the antibiotic in the eye.

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          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 9
          : 4
          : 213-216
          Institute of Experimental Medicine (Director: V. Kusák), Czechoslovak Academy of Sciences, and Department of Ophthalmology (Director: Doc. J. Votocková), Charles University, Prague
          264888 Ophthalmic Res 1977;9:213–216
          © 1977 S. Karger AG, Basel

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          Pages: 4


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