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      Tetracycline: Release from Hydrophilic Gel Contact Lens and Intraocular Penetration

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          Abstract

          Application of tritiated tetracycline by means of hydrophilic gel contact lenses in rabbits revealed that about 20% of the antibiotic was released from the gel during a contact time of 5 h. Abrasion of the epithelium increased the intraocular penetration considerably. No accumulation of tetracycline in the eye tissues was observed even after 72 h of continuous application of contact lenses presoaked in tetracycline. Compared with the instillation of tetracycline solution, the application of contact lenses presoaked in tetracycline is much more effective with respect to the achieved level of the antibiotic in the eye.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1977
          1977
          03 December 2009
          : 9
          : 4
          : 213-216
          Affiliations
          Institute of Experimental Medicine (Director: V. Kusák), Czechoslovak Academy of Sciences, and Department of Ophthalmology (Director: Doc. J. Votocková), Charles University, Prague
          Article
          264888 Ophthalmic Res 1977;9:213–216
          10.1159/000264888
          © 1977 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 4
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