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      Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality.

      Psychiatry Research
      Adult, Aged, Chi-Square Distribution, Chromosomes, Human, Pair 11, genetics, Female, Genetic Markers, Haplotypes, Humans, Incidence, Male, Middle Aged, Polymorphism, Genetic, Protein Isoforms, Schizophrenia, enzymology, epidemiology, Suicide, Attempted, statistics & numerical data, Tryptophan Hydroxylase, metabolism

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          Abstract

          Allele and haplotype frequencies of a promoter polymorphism in the gene encoding tryptophan hydroxylase (TPH2) did not differ in 83 suicidal schizophrenic patients compared with 170 non-suicidal schizophrenic patients. These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behavior in schizophrenia.

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