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      Use of Topical Clotrimazole in Human Keratomycosis

      Ophthalmologica

      S. Karger AG

      Clotrimazole, topical, Imidazole, Keratomycosis

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          Abstract

          Twelve out of 15 patients (9 males and 6 females) with laboratory-proven fungal keratitis were treated with topical clotrimazole, a synthetic imidazole derivative. Their ages ranged from 8 to 70 years. The posttreatment visual acuities were significantly better than the pretreatment visual acuities. No significant biomicroscopic signs of ocular surface toxicity were noted. The ocular condition in 3 patients (all infected with Fusarium solani) deteriorated to blindness despite the antifungal therapy. Conclusion: The clotrimazole usually marketed as dermatological preparation can be used in a diluted form to treat human keratomycosis safely and successfully. A combination with a polyene derivative should be considered in the treatment of fungal corneal infection due to Fusarium spp.

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          Author and article information

          Journal
          OPH
          Ophthalmologica
          10.1159/issn.0030-3755
          Ophthalmologica
          S. Karger AG
          0030-3755
          1423-0267
          2001
          October 2001
          17 August 2001
          : 215
          : 5
          : 357-360
          Affiliations
          Dar es Salaam, Tanzania
          Article
          50885 Ophthalmologica 2001;215:357–360
          10.1159/000050885
          11528261
          © 2001 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 2, Tables: 2, References: 13, Pages: 4
          Categories
          Original Paper · Travail original · Originalarbeit

          Vision sciences, Ophthalmology & Optometry, Pathology

          Clotrimazole, topical, Keratomycosis, Imidazole

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