0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Effects of dopamine D2/3 and opioid receptor antagonism on the trade-off between model-based and model-free behaviour in healthy volunteers

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Human behaviour requires flexible arbitration between actions we do out of habit and actions that are directed towards a specific goal. Drugs that target opioid and dopamine receptors are notorious for inducing maladaptive habitual drug consumption; yet, how the opioidergic and dopaminergic neurotransmitter systems contribute to the arbitration between habitual and goal-directed behaviour is poorly understood. By combining pharmacological challenges with a well-established decision-making task and a novel computational model, we show that the administration of the dopamine D2/3 receptor antagonist amisulpride led to an increase in goal-directed or ‘model-based’ relative to habitual or ‘model-free’ behaviour, whereas the non-selective opioid receptor antagonist naltrexone had no appreciable effect. The effect of amisulpride on model-based/model-free behaviour did not scale with drug serum levels in the blood. Furthermore, participants with higher amisulpride serum levels showed higher explorative behaviour. These findings highlight the distinct functional contributions of dopamine and opioid receptors to goal-directed and habitual behaviour and support the notion that even small doses of amisulpride promote flexible application of cognitive control.

          Related collections

          Most cited references107

          • Record: found
          • Abstract: not found
          • Article: not found

          World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.

          (2013)
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Inference from Iterative Simulation Using Multiple Sequences

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              brms: An R Package for Bayesian Multilevel Models Using Stan

                Bookmark

                Author and article information

                Contributors
                Role: Reviewing Editor
                Role: Senior Editor
                Journal
                eLife
                Elife
                eLife
                eLife
                eLife Sciences Publications, Ltd
                2050-084X
                05 December 2022
                2022
                : 11
                : e79661
                Affiliations
                [1 ] Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna ( https://ror.org/03prydq77) Vienna Austria
                [2 ] Interacting Minds Centre, Aarhus University ( https://ror.org/01aj84f44) Aarhus Denmark
                [3 ] Department of Psychology, University of Essex ( https://ror.org/02nkf1q06) Colchester United Kingdom
                [4 ] Department of Clinical and Health Psychology, Faculty of Psychology, University of Vienna ( https://ror.org/03prydq77) Vienna Austria
                [5 ] FDZ‐Forensisches DNA Zentrallabor GmbH, Medical University of Vienna ( https://ror.org/05n3x4p02) Vienna Austria
                [6 ] Department of Psychiatry and Psychotherapy, Medical University of Vienna ( https://ror.org/05n3x4p02) Vienna Austria
                [7 ] Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich and ETH Zurich ( https://ror.org/02crff812) Zurich Switzerland
                [8 ] Scuola Internazionale Superiore di Studi Avanzati (SISSA) ( https://ror.org/004fze387) Trieste Italy
                National Institute on Drug Abuse Intramural Research Program ( https://ror.org/00fq5cm18) United States
                University of California, San Diego ( https://ror.org/0168r3w48) United States
                National Institute on Drug Abuse Intramural Research Program ( https://ror.org/00fq5cm18) United States
                National Institute on Drug Abuse Intramural Research Program ( https://ror.org/00fq5cm18) United States
                Author notes
                [†]

                These authors contributed equally to this work.

                [‡]

                Deceased.

                [‡]

                Deceased on the 27th of February 2017.

                Author information
                https://orcid.org/0000-0002-3445-9464
                https://orcid.org/0000-0002-3517-3783
                https://orcid.org/0000-0003-0519-6324
                https://orcid.org/0000-0002-4875-5459
                https://orcid.org/0000-0002-5422-0653
                https://orcid.org/0000-0002-4284-3618
                https://orcid.org/0000-0003-4079-5453
                Article
                79661
                10.7554/eLife.79661
                9721617
                36468832
                711e733b-8a82-423e-80cb-00e6e7f9700a
                © 2022, Mikus et al

                This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

                History
                : 21 April 2022
                : 22 November 2022
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100001821, Vienna Science and Technology Fund;
                Award ID: CS15- 003
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/501100001821, Vienna Science and Technology Fund;
                Award ID: VRG13-007
                Award Recipient :
                The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
                Categories
                Research Article
                Neuroscience
                Custom metadata
                Blocking D2 dopamine receptors increases goal-directed (“model-based”) control when alternative habitual ("model-free") actions are available, whereas blocking opioid receptors does not seem to have an effect on the arbitration between the two modes of acting.

                Life sciences
                reinforcement learning,cognitive control,decision-making,human
                Life sciences
                reinforcement learning, cognitive control, decision-making, human

                Comments

                Comment on this article