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      Thyroid Function Tests in Children with Congenital Hypothyroidism on L-Thyroxine Treatment

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          The plasma levels of thyroxine (T<sub>4</sub>), triiodothyronine (T<sub>3</sub>), free T<sub>4</sub> (FT<sub>4</sub>), free T3 (FT<sub>3</sub>), reverse T3 (rT<sub>3</sub>) and immunoradiometrically assayed thyrotropin (IRMA TSH) have been measured in 28 L-T<sub>4</sub>-treated children with congenital hypothyroidism as well as in a control group (group C). The patients were subdivided into 2 groups according to the nonsuppressed (group A) or suppressed (group B) TSH response to TSH-releasing hormone (TRH). Basal IRMA TSH correlated with the TSH increment after TRH and it was significantly lower in group B vs. groups A and C, while no difference was present between groups A and B in regard to T<sub>4</sub>, FT<sub>4</sub> and rT<sub>3</sub>, all higher than in group C. FT<sub>3</sub> levels were similar in the 3 groups. In children, as in adults, basal IRMA TSH seems to be a reliable index in monitoring overtreatment.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 32
          : 4
          : 109-112
          Department of Pediatrics, University of Parma, Italy
          181270 Horm Res 1989;32:109–112
          © 1989 S. Karger AG, Basel

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          Pages: 4
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