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      Correlação entre os níveis séricos de DDT e os títulos de anticorpos antidiftéricos em meninas Translated title: Correlation between DDT serum levels and the diphtheric antibody titer in the female

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          Abstract

          Foram determinados níveis séricos de DDT e títulos de anticorpos antidiftéricos em 28 meninas vacinadas, com a finalidade de estabelecer uma possível correlação. Para a determinação dos níveis de DDT empregou-se o método da cromatografia gasosa. Para a titulação de anticorpos empregou-se o método da inibição da hemaglutinação passiva. A análise estatística dos resultados, feita por métodos não paramétricos, mostrou existir correlação positiva entre presença de op'DDT, quantidade de pp'DDT e títulos de anticorpos. A possível influência do DDT no sistema AMP-cíclico das células imunocomponentes é discutida no trabalho, tentando explicar a correlação positiva encontrada.

          Translated abstract

          Diphtheric antibody titer and blood levels of DDT were determined in 28 female children in order to establish some possible correlation between the two. To measure the DDT level in the blood, the gas chromatographic method was employed; to titrate the antibodies, passive hemagglatination-inhition was performed. The presence of op'DDT and the amount of pp'DDT were statistically correlated to the titer, and a positive correlation was established by non-parametric statistical methods. The possible influence of DDT on the cyclic AMP system of immune-active cells is discussed explaining these results.

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          Most cited references44

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          Alteration of induced cellular and humoral immune responses by pesticides and chemicals of environmental concern: quantitative studies of immunosuppression by DDT, aroclor 1254, carbaryl, carbofuran, and methylparathion.

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            Effects of Acute and Chronic DDT Administration on Hepatic Microsomal Drug Metabolism in the Rat.

            J Fouts, L Hart (1963)
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              Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.

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                Author and article information

                Journal
                rsp
                Revista de Saúde Pública
                Rev. Saúde Pública
                Faculdade de Saúde Pública da Universidade de São Paulo (São Paulo, SP, Brazil )
                0034-8910
                1518-8787
                March 1979
                : 13
                : 1
                : 32-42
                Affiliations
                [01] São Paulo SP orgnameUniversidade de São Paulo orgdiv1Faculdade de Medicina orgdiv2Departamento de Pediatria Brasil
                Article
                S0034-89101979000100005 S0034-8910(79)01300105
                7132f4ca-9859-43d8-bb39-ad78899249cb

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 57, Pages: 11
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                Self URI: Texto completo somente em PDF (PT)
                Categories
                Artigos Originais

                Child,Cyclic AMP,Crianças,DDT,Antibodies, diphtheric,Anticorpos antidiftéricos,AMP cíclica

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