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      Treatment of metastatic melanoma: an overview.

      1 , ,
      Oncology (Williston Park, N.Y.)

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          Abstract

          The 10-year survival rate for patients with metastatic melanoma is less than 10%. Although surgery and radiation therapy have a role in the treatment of metastatic disease, systemic therapy is the mainstay of treatment for most patients. Single-agent chemotherapy is well tolerated but is associated with response rates of only 5% to 20%. Combination chemotherapy and biochemotherapy may improve objective response rates but do not extend survival and are associated with greater toxicity. Immunotherapeutic approaches such as high-dose interleukin-2 are associated with durable responses in a small percentage of patients. In this article, we review the treatments for metastatic melanoma including promising investigational approaches.

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          Author and article information

          Journal
          Oncology (Williston Park)
          Oncology (Williston Park, N.Y.)
          0890-9091
          0890-9091
          May 2009
          : 23
          : 6
          Affiliations
          [1 ] Department of Medicine, Division of Medical Oncology, University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, Washington 98109, USA. sbhatia@u.washington.edu
          Article
          NIHMS129601 165947
          2737459
          19544689
          71361401-90f7-481e-a96c-193e7aa7744b
          History

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