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      Systemic Hemodynamics in Nephrotoxic Acute Renal Failure

      S. Karger AG
      HgCl2 , Acute tubular necrosis, Cardiac output, Renal blood flow

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          Cardiac output (CO) and renal blood flow (RBF) were simultaneously evaluated (microsphere method) in awake rats, 3, 6, and 24 h after induction of acute renal failure by mercuric chloride (HgCl<sub>2</sub>; 4.7 mg/kg body weight). 3 h after injection of HgCl<sub>2</sub> CO and RBF decreased to 77 and 72% of respective control values of 32.0 ± 2.4 and 4.65 ± 0.44 ml/min/100 g. Renal vascular resistance (RVR) and total peripheral resistance (TPR) were significantly increased compared to control at this time. Similar results were observed 6 h after administration of HgCl<sub>2</sub>. Volume expansion with plasma (2% of body weight) restored CO, RBF, TPR, and RVR to normal 3 h after injection of HgCl<sub>2</sub>. Despite significantly elevated blood urea nitrogen 24 h after injection of HgCl<sub>2</sub> (103.7 mg%), all hemodynamic parameters were within control range. Plasma volume was normal 3 h after HgCl<sub>2</sub> but was significantly elevated compared to control 24 h after HgCl<sub>2</sub> (4.73 vs. 3.92 ml/l00 g, p < 0.01). These findings indicate that factors other than preferential renal vasoconstriction may be involved in the transient renal ischemia of HgCl<sub>2</sub>-induced acute renal failure.

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          Author and article information

          S. Karger AG
          02 December 2008
          : 21
          : 2
          : 100-106
          Nephrology Division, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich.
          181377 Nephron 1978;21:100–106
          © 1978 S. Karger AG, Basel

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          : 15 November 1976
          : 08 August 1977
          Page count
          Pages: 7
          Original Paper

          Cardiovascular Medicine,Nephrology
          HgCl2 ,Acute tubular necrosis,Cardiac output,Renal blood flow
          Cardiovascular Medicine, Nephrology
          HgCl2 , Acute tubular necrosis, Cardiac output, Renal blood flow


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