Effect of curcumin (Curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK.

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Abstract

Curcumin, a biphenolic compound extracted from turmeric (Curcuma longa), possesses potent anti-inflammatory activity. The present study investigated whether curcumin could increase 5' adenosine monophosphate-activated protein kinase (AMPK) activity in macrophages and modulate the severity of lipopolysaccharide (LPS)-induced acute lung injury.

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Journal

Journal ID (iso-abbrev): J Anesth

Title: Journal of anesthesia

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1438-8359

ISSN (Print): 0913-8668

Publication date (Electronic): Feb 2016

Volume: 30

Issue: 1

Affiliations

[1 ] Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School and Hospital, 5 Hak dong, Gwangju, 501-746, Korea.

[2 ] Research Institute of Medical Sciences, Chonnam National University, Gwangju, Korea.

[3 ] Departments of Anesthesiology and Pain Medicine, Chonnam National University Medical School and Hospital, 5 Hak dong, Gwangju, 501-746, Korea. nextphil2@jnu.ac.kr.

[4 ] Research Institute of Medical Sciences, Chonnam National University, Gwangju, Korea. nextphil2@jnu.ac.kr.

Article

Publisher Item ID: 10.1007/s00540-015-2073-1

DOI: 10.1007/s00540-015-2073-1

PubMed ID: 26335543

SO-VID: 7139ab25-a904-4004-9209-cad4e9d563d5

History

Keywords: AMPK,CaMKK,Curcumin,LPS,Macrophage

Data availability:

Keywords: AMPK, CaMKK, Curcumin, LPS, Macrophage

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