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      Assessing hydroxychloroquine toxicity by the multifocal ERG.

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          Abstract

          Twenty patients on Plaquenil treatment were evaluated for retinal toxicity using the (EOG) and the mfERG. Group 1 comprises 15 patients (30 eyes) with normal EOG. From these patients 11 (22 eyes) showed normal RRD of mfERG in area 1 and area 2. The rest four patients (8 eyes) the RRD were reduced. Six months after interruption of HC, the mfERG improved in three cases. Group 2 comprises 5 patients (10 eyes) with subnormal EOG. Four (8 eyes) of these showed a decrease of RRD of the mfERG in area 1 and 2. In the rest one (2 eyes) the RRD were normal. Six months after interruption of HC the mfERG and the EOG improved in 2 cases. These results postulate that the mfERG may be used as an alternative method, perhaps more sensitive, for the detection of the HC retinopathy and the follow up of the patients on hydroxychloroquine.

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          Author and article information

          Journal
          Doc Ophthalmol
          Documenta ophthalmologica. Advances in ophthalmology
          0012-4486
          0012-4486
          Jan 2004
          : 108
          : 1
          Affiliations
          [1 ] Department of Ophthalmology, University of Athens, Greece. mosxos@hellasnet.gr
          Article
          10.1023/B:DOOP.0000018385.99215.0d
          15104166
          713b3a88-e41d-43a6-ad03-f7b687e576e2
          History

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