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      Ventral pallidum roles in reward and motivation

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      Behavioural Brain Research

      Elsevier BV

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          Abstract

          In recent years the ventral pallidum has become a focus of great research interest as a mechanism of reward and incentive motivation. As a major output for limbic signals, the ventral pallidum was once associated primarily with motor functions rather than regarded as a reward structure in its own right. However, ample evidence now suggests that ventral pallidum function is a major mechanism of reward in the brain. We review data indicating that (1) an intact ventral pallidum is necessary for normal reward and motivation, (2) stimulated activation of ventral pallidum is sufficient to cause reward and motivation enhancements, and (3) activation patterns in ventral pallidum neurons specifically encode reward and motivation signals via phasic bursts of excitation to incentive and hedonic stimuli. We conclude that the ventral pallidum may serve as an important 'limbic final common pathway' for mesocorticolimbic processing of many rewards.

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          Author and article information

          Journal
          Behavioural Brain Research
          Behavioural Brain Research
          Elsevier BV
          01664328
          January 2009
          January 2009
          : 196
          : 2
          : 155-167
          10.1016/j.bbr.2008.09.038
          2606924
          18955088
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

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