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      Modulating the surface potential of microspheres by phase transition in strontium doped barium titanate to restore the electric microenvironment for bone regeneration

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          Abstract

          The endogenous electrical potential generated by native bone and periosteum plays a key role in maintaining bone mass and quality. Inspired by the electrical properties of bone, different negative surface potentials are built on microspheres to restore electric microenvironment for powerful bone regeneration, which was prepared by the combination of strontium-doped barium titanate (Sr-BTO) nanoparticles and poly (lactic-co-glycolic acid) (PLGA) with high electrostatic voltage field (HEV). The surface potential was modulated through regulating the phase composition of nanoparticles in microspheres by the doping amount of strontium ion (Sr 2+). As a result, the 0.1Sr-BTO/PLGA group shows the lowest surface potential and its relative permittivity is closer to natural bone. As expected, the 0.1Sr-BTO/PLGA microspheres performed cytocompatibility, osteogenic activity in vitro and enhance bone regeneration in vivo. Furthermore, the potential mechanism of Sr-BTO/PLGA microspheres to promote osteogenic differentiation was further explored. The lower surface potential generated on Sr-BTO/PLGA microspheres regulates cell membrane potential and leads to an increase in the intracellular calcium ion (Ca 2+) concentration, which could activate the Calcineurin (CaN)/Nuclear factor of activated T-cells (NFAT) signaling pathway to promote osteogenic differentiation. This study established an effective method to modulate the surface potential, which provides a prospective exploration for electrical stimulation therapy. The 0.1Sr-BTO/PLGA microsphere with lower surface potential and bone-matched dielectric constant is expected to have great potential in the field of bone regeneration.

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          Most cited references43

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          On the Piezoelectric Effect of Bone

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            The development of collagen based composite scaffolds for bone regeneration

            Bone is consisted of bone matrix, cells and bioactive factors, and bone matrix is the combination of inorganic minerals and organic polymers. Type I collagen fibril made of five triple-helical collagen chains is the main organic polymer in bone matrix. It plays an important role in the bone formation and remodeling process. Moreover, collagen is one of the most commonly used scaffold materials for bone tissue engineering due to its excellent biocompatibility and biodegradability. However, the low mechanical strength and osteoinductivity of collagen limit its wider applications in bone regeneration field. By incorporating different biomaterials, the properties such as porosity, structural stability, osteoinductivity, osteogenicity of collagen matrixes can be largely improved. This review summarizes and categorizes different kinds of biomaterials including bioceramic, carbon and polymer materials used as components to fabricate collagen based composite scaffolds for bone regeneration. Moreover, the possible directions of future research and development in this field are also proposed.
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              Pharmaceutical electrospinning and 3D printing scaffold design for bone regeneration

                Author and article information

                Contributors
                Journal
                Front Bioeng Biotechnol
                Front Bioeng Biotechnol
                Front. Bioeng. Biotechnol.
                Frontiers in Bioengineering and Biotechnology
                Frontiers Media S.A.
                2296-4185
                30 August 2022
                2022
                : 10
                : 988300
                Affiliations
                [1] 1 Key Laboratory of Polymer Ecomaterials , Changchun Institute of Applied Chemistry , Chinese Academy of Sciences , Changchun, China
                [2] 2 School of Applied Chemistry and Engineering , University of Science and Technology of China , Hefei, China
                [3] 3 Department of Ophthalmology , Third Medical Center , Chinese PLA General Hospital , Beijing, China
                [4] 4 8th Department of Orthopaedics , Foshan Hospital of Traditional Chinese Medicine , Foshan, China
                Author notes

                Edited by: Jiang Pi, Guangdong meidcal University, China

                Reviewed by: Zhiwei Fang, Johns Hopkins University, United States

                Fengxuan Han, Soochow University, China

                *Correspondence: Peibiao Zhang, zhangpb@ 123456ciac.ac.cn ; Min Guo, guomin@ 123456ciac.ac.cn

                This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology

                Article
                988300
                10.3389/fbioe.2022.988300
                9468715
                714afca8-d40a-471b-924e-cfca9dcc09f7
                Copyright © 2022 Wang, Zhou, Lv, Wang, Wang, Wang, Zhu, Guo and Zhang.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 07 July 2022
                : 08 August 2022
                Funding
                Funded by: National Natural Science Foundation of China , doi 10.13039/501100001809;
                Award ID: 52173146
                Categories
                Bioengineering and Biotechnology
                Original Research

                microsphere,surface potential,dielectric properties,bone regeneration,doped,barium titanate

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