TOOTH (The Open study Of dental pulp stem cell Therapy in Humans): Study protocol for evaluating safety and feasibility of autologous human adult dental pulp stem cell therapy in patients with chronic disability after stroke.

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Abstract

Stroke represents a significant global disease burden. As of 2015, there is no chemical or biological therapy proven to actively enhance neurological recovery during the chronic phase post-stroke. Globally, cell-based therapy in stroke is at the stage of clinical translation and may improve neurological function through various mechanisms such as neural replacement, neuroprotection, angiogenesis, immuno-modulation, and neuroplasticity. Preclinical evidence in a rodent model of middle cerebral artery ischemic stroke as reported in four independent studies indicates improvement in neurobehavioral function with adult human dental pulp stem cell therapy. Human adult dental pulp stem cells present an exciting potential therapeutic option for improving post-stroke disability.

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Journal ID (iso-abbrev): Int J Stroke

Title: International journal of stroke : official journal of the International Stroke Society

ISSN (Electronic): 1747-4949

ISSN (Print): 1747-4930

Publication date (Electronic): Jul 2016

Volume: 11

Issue: 5

Affiliations

[1 ] School of Medicine, The University of Adelaide, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia.

[2 ] Neurology Department, The Queen Elizabeth Hospital, Woodville, South Australia School of Medicine, University of Adelaide, Adelaide, South Australia.

[3 ] Neurology Department, The Queen Elizabeth Hospital, Woodville, South Australia.

[4 ] Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia.

[5 ] School of Dental Medicine, University of Pennsylvania, Philadelphia, USA.

[6 ] Neurorehabilitation and Recovery research group, Stroke Division, Florey Institute of Neuroscience and Mental Health La Trobe University, Melbourne, Victoria, Australia School of Allied Health, La Trobe University, Melbourne, Australia.

[7 ] Health Sciences Divisional Office School of Health Sciences, University of South Australia, Adelaide, South Australia.

[8 ] School of Allied Health, La Trobe University, Melbourne, Australia.

[9 ] Department of Neurosurgery, Royal Adelaide Hospital, Adelaide, South Australia.

[10 ] Molecular Imaging and Therapy Research Unit, South Australian Health and Medical Research Institute, Adelaide, South Australia.

[11 ] School of Medicine, University of Adelaide, Adelaide, South Australia SAHMRI & Basil Hetzel Institute, The Queen Elizabeth Hospital, Woodville, South Australia simon.koblar@adelaide.edu.au.

Article

Publisher Item ID: 1747493016641111

DOI: 10.1177/1747493016641111

PubMed ID: 27030504

SO-VID: 714efd8e-de91-4e8e-a32d-640acfdce3cd

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Keywords: Ischemic stroke,adult human dental pulp stem cells,neurobehavioral outcomes,post stroke disability

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Keywords: Ischemic stroke, adult human dental pulp stem cells, neurobehavioral outcomes, post stroke disability

TOOTH (The Open study Of dental pulp stem cell Therapy in Humans): Study protocol for evaluating safety and feasibility of autologous human adult dental pulp stem cell therapy in patients with chronic disability after stroke.

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