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      Blood Viscosity in Experimental Acute Renal Failure

      , ,

      Nephron

      S. Karger AG

      Fibrinogen, Acute renal failure, Blood viscosity

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          Abstract

          We measured blood viscosity in rats 24 h after induction of acute renal failure by glycerol or HgCl<sub>2</sub> injections. The blood viscosity values of rats with acute renal failure were significantly higher than those of controls at any shear rates. The mean values of plasma fibrinogen in animals with glycerol – (302.5 ± 35.1 mg/100 ml) or HgCl<sub>2</sub> -(342.1 ± 15.9 mg/100 ml) induced acute renal failure were significantly elevated compared to control levels (169.6 ± 16.7 mg/100 ml). We believe that the increased blood viscosity in acute renal failure was primarily due to high concentration of plasma fibrinogen. The elevated blood viscosity may affect capillary microvascular circulation of glomerular capillary beds.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 30
          : 4
          : 348-351
          Affiliations
          Department of Internal Medicine, Nephrology Division, University of Michigan, Ann Arbor, Mich., USA
          Article
          182515 Nephron 1982;30:348–351
          10.1159/000182515
          6213875
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Fibrinogen, Acute renal failure, Blood viscosity

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