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      Erratum to “DAB2IP Downregulation Enhances the Proliferation and Metastasis of Human Gastric Cancer Cells by Derepressing the ERK1/2 Pathway”

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          Abstract

          In the article titled “DAB2IP Downregulation Enhances the Proliferation and Metastasis of Human Gastric Cancer Cells by Derepressing the ERK1/2 Pathway” [1], there was an error in Figure 2, where the Western blots in Figures 2(b) and 2(c) were duplicated, due to a production error. The correct figure is as follows.

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          DAB2IP Downregulation Enhances the Proliferation and Metastasis of Human Gastric Cancer Cells by Derepressing the ERK1/2 Pathway

          DAB2IP (DOC2/DAB2 interactive protein) is downregulated in several cancer types, and its downregulation is involved in tumor cell proliferation, apoptosis, metastasis, and epithelial-mesenchymal transition (EMT). We aimed to investigate the potential role of DAB2IP in the development and progression of gastric cancer. DAB2IP levels were analyzed in human gastric cancer and adjacent normal tissues by Western blots and immunohistochemistry. Potential roles of DAB2IP in regulating gastric cancer cell growth and metastasis were examined by genetic manipulation in vitro. The molecular signaling was determined to understand the mechanisms of observed DAB2IP effects. DAB2IP level is lower in gastric cancer tissues as compared to paired normal tissues. Knockdown of DAB2IP enhanced gastric cancer cell growth and metastasis in vitro and promoted EMT progress at both protein and mRNA levels. Silencing DAB2IP activated extracellular signal-regulated kinase 1/2 (ERK1/2) pathway, and the enhanced proliferation and migration ability induced by DAB2IP knockdown were reduced after incubation with U0126 in SGC7901 gastric cancer cells. Inhibition of DAB2IP enhances gastric cancer cell growth and metastasis through targeting the ERK1/2 signaling, indicating that it may serve as a potential target for treatment of gastric cancer.
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            Author and article information

            Contributors
            Journal
            Gastroenterol Res Pract
            Gastroenterol Res Pract
            GRP
            Gastroenterology Research and Practice
            Hindawi
            1687-6121
            1687-630X
            2020
            1 April 2020
            1 April 2020
            : 2020
            : 7419534
            Affiliations
            1Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
            2Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
            3Department of Radiation Medicine, Medical College of Soochow University, Suzhou 215006, China
            4Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
            Author information
            https://orcid.org/0000-0002-2721-1866
            https://orcid.org/0000-0002-0081-6515
            https://orcid.org/0000-0003-4444-6920
            Article
            10.1155/2020/7419534
            7152946
            715b1efb-7a31-4226-947b-b037c5c85459
            Copyright © 2020 Liang Sun et al.

            This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

            History
            : 24 October 2019
            : 31 October 2019
            Categories
            Erratum

            Gastroenterology & Hepatology
            Gastroenterology & Hepatology

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