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      Direct Effects of Gonadotropin-Releasing Hormone on the Ovary in Rats and Humans

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          Abstract

          In order to know whether gonadotropin-releasing hormone (GnRH)-like substances play a role as local regulators in the ovary, localization of the GnRH receptor, and the effects of GnRH agonist (GnRHa) on the cyclic AMP system in the rat ovary was studied. In addition, effects of GnRH antagonist on the rat ovary and effects of GnRHa on steroidogenesis in the human ovary were also examined. In the rat, localization of the GnRH receptor was observed to change with follicular development, and GnRHa decreased follicle-stimulating-hormone-stimulated cAMP production. On the other hand, GnRH antagonist showed the tendency to promote ovarian function. In the human ovary, GnRHa seemed to inhibit steroidogenesis directly, in vivo and in vitro. These data suggested that GnRH/GnRH-like substances play a role as local regulators in the ovary.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-5994-2
          978-3-318-01932-2
          1663-2818
          1663-2826
          1994
          1994
          05 December 2008
          : 41
          : Suppl 1
          : 7-13
          Affiliations
          Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama, Japan
          Article
          183936 Horm Res 1994;41:7–13
          10.1159/000183936
          8088696
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Local Regulators in the Ovary – Paracrine and Autocrine Control

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