Direct Effects of Gonadotropin-Releasing Hormone on the Ovary in Rats and Humans

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Abstract

In order to know whether gonadotropin-releasing hormone (GnRH)-like substances play a role as local regulators in the ovary, localization of the GnRH receptor, and the effects of GnRH agonist (GnRHa) on the cyclic AMP system in the rat ovary was studied. In addition, effects of GnRH antagonist on the rat ovary and effects of GnRHa on steroidogenesis in the human ovary were also examined. In the rat, localization of the GnRH receptor was observed to change with follicular development, and GnRHa decreased follicle-stimulating-hormone-stimulated cAMP production. On the other hand, GnRH antagonist showed the tendency to promote ovarian function. In the human ovary, GnRHa seemed to inhibit steroidogenesis directly, in vivo and in vitro. These data suggested that GnRH/GnRH-like substances play a role as local regulators in the ovary.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISBN: 978-3-8055-5994-2

ISBN: 978-3-318-01932-2

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1994

Publication date (Print): 1994

Publication date (Electronic): 05 December 2008

Volume: 41

Issue: Suppl 1

Pages: 7-13

Affiliations

Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama, Japan

Article

Publisher ID: 183936 Other ID: Horm Res 1994;41:7–13

DOI: 10.1159/000183936

PubMed ID: 8088696

SO-VID: 715b9529-dc66-4ed6-8adf-c0a048186a00

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Direct Effects of Gonadotropin-Releasing Hormone on the Ovary in Rats and Humans

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Karger: Endocrinology

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