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      Direct Effects of Gonadotropin-Releasing Hormone on the Ovary in Rats and Humans

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          In order to know whether gonadotropin-releasing hormone (GnRH)-like substances play a role as local regulators in the ovary, localization of the GnRH receptor, and the effects of GnRH agonist (GnRHa) on the cyclic AMP system in the rat ovary was studied. In addition, effects of GnRH antagonist on the rat ovary and effects of GnRHa on steroidogenesis in the human ovary were also examined. In the rat, localization of the GnRH receptor was observed to change with follicular development, and GnRHa decreased follicle-stimulating-hormone-stimulated cAMP production. On the other hand, GnRH antagonist showed the tendency to promote ovarian function. In the human ovary, GnRHa seemed to inhibit steroidogenesis directly, in vivo and in vitro. These data suggested that GnRH/GnRH-like substances play a role as local regulators in the ovary.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          05 December 2008
          : 41
          : Suppl 1
          : 7-13
          Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama, Japan
          183936 Horm Res 1994;41:7–13
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 7
          Local Regulators in the Ovary – Paracrine and Autocrine Control


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