Blog
About

17
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Intercellular junction assembly, dynamics, and homeostasis.

      Cold Spring Harbor perspectives in biology

      Models, Biological, physiology, Intermediate Filaments, Intercellular Junctions, Humans, Homeostasis, Endocytosis, Desmosomes, metabolism, Cytoskeleton, Cell Membrane, Cell Adhesion, Cadherins, Animals, Adherens Junctions

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Intercellular anchoring junctions are highly specialized regions of the plasma membrane where members of the cadherin family of transmembrane adhesion molecules on opposing cells interact through their extracellular domains, and through their cytoplasmic domains serve as a platform for organizing cytoskeletal anchors and remodelers. Here we focus on assembly of so-called "anchoring" or "adhering" junctions-adherens junctions (AJs) and desmosomes (DSMs), which associate with actin and intermediate filaments, respectively. We will examine how the assembly and function of AJs and DSMs are intimately connected during embryogenesis and in adult cells and tissues, and in some cases even form specialized "mixed" junctions. We will explore signaling and trafficking machineries that drive assembly and remodeling and how these mechanisms are co-opted in human disease.

          Related collections

          Author and article information

          Journal
          10.1101/cshperspect.a000125
          2828282
          20182611

          Comments

          Comment on this article