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      Synthetic Ovine Corticotropin-Releasing Factor Stimulates Adrenocorticotropin Release in the Ovine Fetus over the Last Fifth of Gestation

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          Abstract

          Synthetic ovine corticotropin-releasing factor (0.1–1.0 µg) was injected intravenously to 6 chronically cannulated ovine fetuses between 104 and 149 days of gestation (term 142–152 days). Arterial plasma immunoreactive adrenocorticotropin was first elevated by this procedure if the fetuses were between 118 and 130 days of gestation, and an increased response occurred later in gestation. This suggests that a progressive reset of the hypothalamic-pituitary-adrenal feedback relationship occurs over the last 2–3 weeks of gestation in the ovine fetus.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1984
          1984
          28 March 2008
          : 38
          : 1
          : 86-87
          Affiliations
          aPhysiology Department and bHoward Florey Institute for Experimental Physiology and Medecine, University of Melbourne, Parkville, Australia
          Article
          123870 Neuroendocrinology 1984;38:86–87
          10.1159/000123870
          6320033
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 2
          Categories
          Rapid Communication

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