Tumor microenvironment complexity and therapeutic implications at a glance

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Abstract

The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to increase the multidrug resistance ending in cancer cell progression and metastasis. The reciprocal cell-cell/ECM interaction and tumor cell hijacking of non-malignant cells force stromal cells to lose their function and acquire new phenotypes that promote development and invasion of tumor cells. Understanding the underlying cellular and molecular mechanisms governing these interactions can be used as a novel strategy to indirectly disrupt cancer cell interplay and contribute to the development of efficient and safe therapeutic strategies to fight cancer. Furthermore, the tumor-derived circulating materials can also be used as cancer diagnostic tools to precisely predict and monitor the outcome of therapy. This review evaluates such potentials in various advanced cancer models, with a focus on 3D systems as well as lab-on-chip devices.

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Most cited references 226

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Microenvironmental regulation of tumor progression and metastasis.

Daniela F Quail, Johanna A Joyce (2013)

Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive therapeutic target with reduced risk of resistance and tumor recurrence. However, specifically disrupting the pro-tumorigenic TME is a challenging undertaking, as the TME has diverse capacities to induce both beneficial and adverse consequences for tumorigenesis. Furthermore, many studies have shown that the microenvironment is capable of normalizing tumor cells, suggesting that re-education of stromal cells, rather than targeted ablation per se, may be an effective strategy for treating cancer. Here we discuss the paradoxical roles of the TME during specific stages of cancer progression and metastasis, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.

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Tumour exosome integrins determine organotropic metastasis

Ayuko Hoshino, Bruno Costa-Silva, Tang-Long Shen … (2015)

Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics revealed distinct integrin expression patterns, in which the exosomal integrins α6β4 and α6β1 were associated with lung metastasis, while exosomal integrin αvβ5 was linked to liver metastasis. Targeting the integrins α6β4 and αvβ5 decreased exosome uptake, as well as lung and liver metastasis, respectively. We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression. Finally, our clinical data indicate that exosomal integrins could be used to predict organ-specific metastasis.

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Tumour-associated macrophages as treatment targets in oncology

Alberto Mantovani, Federica Marchesi, Alberto Malesci … (2017)

Tumour-associated macrophages (TAMs) are key drivers of tumour-promoting inflammation and cancer progression, and are important determinants of responsiveness to a range of therapies. Herein, the authors summarize the roles of TAMs in cancer, and discuss the potential of TAM-targeted therapeutic strategies to complement and synergize with other anticancer treatments.

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Author and article information

Contributors

Roghayyeh Baghban: baghbanroghayyeh@gmail.com

Leila Roshangar: lroshangar@yahoo.com

Rana Jahanban-Esfahlan: Jahanbanr@tbzmed.ac.ir

Khaled Seidi: Kh.seidi@yahoo.com

Abbas Ebrahimi-Kalan: abbasebra@gmail.com

Mehdi Jaymand: m.jaymand@gmail.com

Saeed Kolahian: Saeed.Kolahian@med.uni-tuebingen.de

Tahereh Javaheri: Zohreh.javaheri@gmail.com

Peyman Zare: p.zare@nencki.edu.pl

Journal

Journal ID (nlm-ta): Cell Commun Signal

Journal ID (iso-abbrev): Cell Commun. Signal

Title: Cell Communication and Signaling : CCS

Publisher: BioMed Central (London )

ISSN (Electronic): 1478-811X

Publication date (Electronic): 7 April 2020

Publication date PMC-release: 7 April 2020

Publication date Collection: 2020

Volume: 18

Electronic Location Identifier: 59

Affiliations

[1 ]GRID grid.412888.f, ISNI 0000 0001 2174 8913, Drug Applied Research Center, , Tabriz University of Medical Sciences, ; Tabriz, Iran

[2 ]GRID grid.412888.f, ISNI 0000 0001 2174 8913, Department of Medical Biotechnology, School of Advanced Medical Sciences, , Tabriz University of Medical Sciences, ; Tabriz, Iran

[3 ]GRID grid.412888.f, ISNI 0000 0001 2174 8913, Stem Cell Research Center, , Tabriz University of Medical Sciences, ; Tabriz, Iran

[4 ]GRID grid.412888.f, ISNI 0000 0001 2174 8913, Biotechnology Research Center, , Tabriz University of Medical Sciences, ; Tabriz, Iran

[5 ]GRID grid.412888.f, ISNI 0000 0001 2174 8913, Student Research Committees, , Tabriz University of Medical Sciences, ; Tabriz, Iran

[6 ]GRID grid.412888.f, ISNI 0000 0001 2174 8913, Department of Neurosciences and Cognitive, , School of Advanced Medical Sciences, Tabriz University of Medical Sciences, ; Tabriz, Iran

[7 ]GRID grid.412112.5, ISNI 0000 0001 2012 5829, Nano Drug Delivery Research Center, Health Technology Institute, , Kermanshah University of Medical Sciences, ; Kermanshah, Iran

[8 ]GRID grid.411544.1, ISNI 0000 0001 0196 8249, Department of Experimental and Clinical Pharmacology and Pharmacogenomics, , University Hospital Tuebingen, ; Tuebingen, Germany

[9 ]GRID grid.189504.1, ISNI 0000 0004 1936 7558, Health Informatics Lab, Metropolitan College, , Boston University, ; Boston, USA

[10 ]GRID grid.419305.a, ISNI 0000 0001 1943 2944, Dioscuri Center of Chromatin Biology and Epigenomics, , Nencki Institute of Experimental Biology, Polish Academy of Sciences, ; Warsaw, Poland

[11 ]GRID grid.440603.5, ISNI 0000 0001 2301 5211, Faculty of Medicine, , Cardinal Stefan Wyszyński University in Warsaw, ; 01-938 Warsaw, Poland

Article

Publisher ID: 530

DOI: 10.1186/s12964-020-0530-4

PMC ID: 7140346

PubMed ID: 32264958

SO-VID: 7195b2cb-5acd-4934-9f1e-59530c40e8e9

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 5 December 2019

Date accepted : 5 February 2020

Custom metadata

ScienceOpen disciplines: Cell biology

Keywords: cancer cell interactions,tumor microenvironment,extracellular matrix,cancer therapy,stroma cell,circulating tumor cells,cell-free dna,apoptotic bodies,exosome,horizontal transfer,cancer models

Data availability:

ScienceOpen disciplines: Cell biology

Keywords: cancer cell interactions, tumor microenvironment, extracellular matrix, cancer therapy, stroma cell, circulating tumor cells, cell-free dna, apoptotic bodies, exosome, horizontal transfer, cancer models

Tumor microenvironment complexity and therapeutic implications at a glance

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Most cited references 226

Microenvironmental regulation of tumor progression and metastasis.

Tumour exosome integrins determine organotropic metastasis

Tumour-associated macrophages as treatment targets in oncology

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