0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models

      , , , ,

      Journal of Thoracic Disease

      AME Publishing Company

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          <p class="first" id="d7935640e196">Middle East respiratory syndrome (MERS) is a highly lethal respiratory disease caused by a novel betacoronavirus (MERS coronavirus, MERS-CoV). Since its first emergence in 2012, multiple transmission events of MERS-CoV (dromedary to human and human to human) have been reported, indicating that MERS-CoV has the potential to cause widespread outbreak. However, the epidemiology of MERS as well as immune responses against the virus in animal models and patients are still not well understood, hindering the vaccine and therapeutic developments. In this review, we summarize recent genetic and epidemic findings of MERS-CoV and the progress in animal model development, immune response studies in both animals and humans. At last, we discussed the breakthrough on vaccine and therapeutic development which are important against potential future MERS outbreak. </p>

          Related collections

          Author and article information

          Journal
          Journal of Thoracic Disease
          J. Thorac. Dis.
          AME Publishing Company
          20721439
          20776624
          July 2018
          July 2018
          July 2018
          July 2018
          : 10
          : S9
          : S2260-S2271
          Article
          10.21037/jtd.2018.03.80
          6072923
          30116605
          © 2018
          Product

          Comments

          Comment on this article