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      MRI-Based Volumetry Correlates of Autobiographical Memory in Alzheimer's Disease

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          Abstract

          The aim of the present volumetric study was to explore the neuro-anatomical correlates of autobiographical memory loss in Alzheimer's patients and healthy elderly, in terms of the delay of retention, with a particular interest in the medial temporal lobe structures. Fifteen patients in early stages of the disease and 11 matched control subjects were included in the study. To assess autobiographical memory and the effect of the retention delay, a modified version of the Crovitz test was used according to five periods of life. Autobiographical memory deficits were correlated to local atrophy via structural MRI using Voxel Based Morphometry. We used a ‘lateralized index’ to compare the relative contribution of hippocampal sub-regions (anterior vs posterior, left vs right) according to the different periods of life. Our results confirm the involvement of the hippocampus proper in autobiographical memory retrieval for both recent and very remote encoding periods, with larger aspect for the very remote period on the left side. Contrary to the prominent left-sided involvement for the young adulthood period, the implication of the right hippocampus prevails for the more recent periods and decreases with the remotness of the memories, which might be associated with the visuo-spatial processing of the memories. Finally, we suggest the existence of a rostrocaudal gradient depending on the retention duration, with left anterior aspects specifically related to retrieval deficits of remote memories from the young adulthood period, whereas posterior aspects would result of simultaneous encoding and/or consolidation and retrieval deficit of more recent memories.

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          Most cited references 61

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          Loss of recent memory after bilateral hippocampal lesions.

           B Milner,  W SCOVILLE (1957)
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            Unified segmentation

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              Memory consolidation, retrograde amnesia and the hippocampal complex.

              Results from recent studies of retrograde amnesia following damage to the hippocampal complex of human and non-human subjects have shown that retrograde amnesia is extensive and can encompass much of a subject's lifetime; the degree of loss may depend upon the type of memory assessed. These and other findings suggest that the hippocampal formation and related structures are involved in certain forms of memory (e.g. autobiographical episodic and spatial memory) for as long as they exist and contribute to the transformation and stabilization of other forms of memory stored elsewhere in the brain.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, USA )
                1932-6203
                2012
                10 October 2012
                : 7
                : 10
                Affiliations
                [1 ]Laboratoire d'Imagerie et de Neurosciences Cognitives (UMR 7237), Université de Strasbourg, Centre National de la Recherche Scientifique, Strasbourg, France
                [2 ]Service de Neurologie - Unité de Neuropsychologie, Centre Hospitalo-Universitaire de Strasbourg, Strasbourg, France
                [3 ]Laboratoire des Sciences de l'Image, de l'Informatique et de la Télédétection (UMR 7005), Université de Strasbourg, Centre National de la Recherche Scientifique, Strasbourg, France
                [4 ]Service de Radiologie, Centre Hospitalo-Universitaire de Strasbourg, Strasbourg, France
                University of Cambridge, United Kingdom
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Conceived and designed the experiments: NP LM FB. Performed the experiments: NP AB BC. Analyzed the data: VN OD FR GS. Contributed reagents/materials/analysis tools: VN OD FR GS SK. Wrote the paper: NP AB LM FB.

                Article
                PONE-D-12-10054
                10.1371/journal.pone.0046200
                3468599
                23071546

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                Page count
                Pages: 11
                Funding
                This work was possible thanks to the French “Fondation Alzheimer". GS was supported by a grant from “Région Alsace" (France). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Medicine
                Mental Health
                Psychology
                Cognitive Psychology
                Memory
                Neurology
                Dementia
                Alzheimer Disease
                Cognitive Neurology
                Neurodegenerative Diseases
                Radiology
                Diagnostic Radiology
                Magnetic Resonance Imaging
                Social and Behavioral Sciences
                Psychology
                Cognitive Psychology
                Memory

                Uncategorized

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