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      Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

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          Abstract

          A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation. These same effects are observed upon administration of recombinant OPG into normal mice. In vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner by recombinant OPG. Furthermore, OPG blocks ovariectomy-associated bone loss in rats. These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          April 1997
          April 1997
          : 89
          : 2
          : 309-319
          Article
          10.1016/S0092-8674(00)80209-3
          9108485
          71e88edf-6f46-45d9-9353-9673c7008c12
          © 1997

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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