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      Causation and Disease: The Henle-Koch Postulates Revisited 1

      The Yale Journal of Biology and Medicine

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          Abstract

          The Henle-Koch postulates are reviewed in terms of their full validity in Koch's day and in light of subsequent developments. The changing guidelines developed for viral diseases, for viruses in relation to cancer and to chronic central nervous system infection, and for causative agents in chronic diseases are discussed chronologically. A set of guidelines for both acute infectious and chronic diseases is presented. The need for recognizing the role of the host and the spectrum of host responses, for sound biologic sense in evaluating causal roles of agents in disease, and for flexibility in adapting our guidelines to new knowledge are emphasized.

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          Author and article information

          Journal
          Yale J Biol Med
          The Yale Journal of Biology and Medicine
          0044-0086
          1551-4056
          May 1976
          : 49
          : 2
          : 175-195
          Author notes
          [1]

          The helpful criticism and encouragement in the preparation of this manuscript by Dr. Abraham Lilienfeld, Professor of Epidemiology, Johns Hopkins School of Hygiene and Public Health, is gratefully acknowledged. I also wish to thank Drs. Werner Henle, Robert Huebner, Richard Johnson, and Abraham Lilienfeld for their photographs and permission to include them.

          This work was supported by grants from the National Cancer Institute (CA-12952) and the National Institute of Allergy and Infectious Diseases (AI08731).

          Article
          2595276
          782050
          Categories
          Medical Essay

          Medicine

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