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      Dendritic cells display subset and tissue-specific maturation dynamics over human life

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          SUMMARY

          Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology, but remains poorly defined in humans. Using our organ donor tissue resource, we analyzed cDC subset distribution, maturation and migration in mucosal tissues (lungs, intestines), associated lymph nodes (LNs), and other lymphoid sites from 78 individuals aged <1–93years. The distribution of cDC1 (CD141 hiCD13 hi) and cDC2 (Sirp-α +CD1c +) subsets was a function of tissue site and conserved between donors. We identified cDC2 as the major mature (HLA-DR hi) subset in LNs with the highest frequency in lung-draining LNs. Mature cDC2 in mucosal-draining LNs expressed tissue-specific markers derived from the paired mucosal site, reflecting their tissue-migratory origin. These distribution and maturation patterns were largely maintained throughout life, with site-specific variations. Our findings provide evidence for localized DC tissue surveillance and reveal a lifelong division of labor between DC subsets, with cDC2 functioning as guardians of the mucosa.

          eTOC Blurb

          Dendritic cells (DCs) function as tissue sentinels, but this role is difficult to study in humans. In this issue of Immunity, Granot et al. show through analysis of lymphoid and mucosal tissues that human DC maturation is tissue-specific, associated with migration phenotypes, and is predominantly observed among the cDC2 subset.

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          Author and article information

          Journal
          9432918
          8591
          Immunity
          Immunity
          Immunity
          1074-7613
          1097-4180
          17 March 2017
          21 March 2017
          21 March 2018
          : 46
          : 3
          : 504-515
          Affiliations
          [1 ]Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032
          [2 ]Department of Medicine, Columbia University Medical Center, New York, NY 10032
          [3 ]Department of Surgery, Columbia University Medical Center, New York, NY 10032
          [4 ]Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032
          [5 ]Division of Critical Care, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032
          [6 ]Department of Pathology, NYU Langone Medical Center
          [7 ]LiveOnNY, New York, NY 10001
          Author notes
          [* ]Correspondence and Lead Contact: df2396@ 123456cumc.columbia.edu
          Article
          PMC5415308 PMC5415308 5415308 nihpa857948
          10.1016/j.immuni.2017.02.019
          5415308
          28329707
          720644be-3c0c-4ed6-ba9b-48be8d9cfc58
          History
          Categories
          Article

          Human Immunology,Dendritic cells,Tissue immunity,Mucosal Immunity

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