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      Open Sesame: a new generation journal

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      BJPsych open
      The Royal College of Psychiatrists

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          Abstract

          Summary

          The Royal College of Psychiatrists welcomes you to its newest peer-reviewed research journal, British Journal of Psychiatry Open ( BJPsych Open), which has been created to maximise the College’s efforts to publish and disseminate the most exciting and progressive research in psychiatry and allied disciplines. BJPsych Open will maintain the same high quality standards established by the British Journal of Psychiatry ( BJPsych). As an online journal without print restrictions, BJPsych Open will be able to publish many more excellent articles and article types not currently accommodated within BJPsych. The breadth of BJPsych Open is outlined in ‘What we publish’ and its strength is realised in our first issue, ‘Powerful papers’. As editors, we welcome both your submissions and comments as our new generation journal grows.

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          Copyright and usage

          © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.

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          Familial risk and childhood adversity interplay in the onset of psychosis

          Background The association between childhood adversity and psychosis in adulthood is well established. However, genetic factors might confound or moderate this association. Aims Using a catchment-based case–control sample, we explored the main effects of, and interplay between, childhood adversity and family psychiatric history on the onset of psychosis. Method Childhood adversity (parental separation and death, physical and sexual abuse) was assessed retrospectively in 224 individuals with a first presentation of psychosis and 256 community controls from South London, UK. Occurrence of psychotic and affective disorders in first-degree relatives was ascertained with the Family Interview for Genetic Studies (FIGS). Results Parental history of psychosis did not confound the association between childhood adversity and psychotic disorder. There was no evidence that childhood adversity and familial liability combined synergistically to increase odds of psychosis beyond the effect of each individually. Conclusions Our results do not support the hypothesis that family psychiatric history amplifies the effect of childhood adversity on odds of psychosis. Declaration of interest None. Copyright and usage © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence.
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            Ethical considerations in placebo-controlled randomised clinical trials

            Summary Ethical considerations in standard medical care and clinical research are underpinnings to quality medicine. Similarly, the placebo-controlled double-blind randomised clinical trial is the gold standard for medical research and fundamental to the development of evidence-based medicine. Researchers and clinicians are challenged by ethical concerns in the informed consent with a need to maximise understanding and minimise therapeutic misconception. This editorial expands on themes raised by Chen et al’s article ‘Disclosing the Potential Impact of Placebo Controls in Antidepressant Trials’ and serves as an invitation for further submissions to BJPsych Open on ethics, research design and informed consent. Declaration of interest None. Copyright and usage © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
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              Unrecognised psychopathology in patients with difficult asthma: major mental and personality disorders

              Background Difficult asthma is a severe subgroup of asthma in which the main feature is uncontrollability of symptoms. Psychopathology is suggested to be prominent in patients with difficult asthma and considered important in its treatment; however, the evidence is scarce. Aims To describe psychopathology in difficult asthma, both major mental and personality disorders, based on diagnostic interviews. Method This study was conducted in a specialised asthma care centre. A total of 51 patients with difficult asthma were diagnosed at the start of the treatment programme using two structured clinical interviews for both major mental (SCID-I) and personality disorders (SCID-II) according to DSM-IV-TR. Results About 55% of the patients with difficult asthma had a psychiatric disorder of which 89% was undiagnosed and untreated before being interviewed. About 49% had a minimum of one major mental disorder of which the cluster of anxiety disorders was the most common cluster of major mental disorders, followed by somatoform disorders. About 20% were diagnosed with a personality disorder. Of the 10 patients with a personality disorder, 9 had an obsessive–compulsive personality disorder. Conclusions This study demonstrates that more than half of patients with difficult asthma had a psychiatric disorder of which 89% was unrecognised. This study highlights the importance of offering patients with difficult asthma a psychiatric diagnostic interview and/or a psychiatric consultation as part of their routine medical examination and provision of appropriate psychiatric treatment. Moreover, it highlights the urgency of further research into the role of psychopathology in the development of difficult asthma. Declaration of interest None. Copyright and usage © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
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                Author and article information

                Journal
                BJPsych Open
                BJPsych Open
                bjporcpsych
                bjporcpsych
                BJPsych open
                The Royal College of Psychiatrists
                2056-4724
                30 June 2015
                June 2015
                : 1
                : 1
                : e1-e2
                Affiliations
                [1] Kamaldeep Bhui, Editor in Chief, Professor of Cultural Psychiatry and Epidemiology at Queen Mary University of London, Honorary Consultant Psychiatrist, East London Foundation Trust, London, UK
                [2] Gin Mahli, Deputy Editor, Chair of Psychiatry, University of Sydney, Australia
                [3] Kenneth R. Kaufman, Deputy Editor, Professor of Psychiatry, Neurology and Anesthesiology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
                Author notes
                Correspondence: Kamaldeep Bhui, Barts and The London School of Medicine and Dentistry, Old Anatomy Building, Charterhouse Square, London EC1M 6BQ, UK. Email: k.s.bhui@ 123456qmul.ac.uk
                Article
                bjporcpsych_1_1_e1
                10.1192/bjpo.bp.115.001263
                5000493
                27703732
                721e40e2-a94d-4ebd-929a-23e3f405c703
                © 2015 The Royal College of Psychiatrists

                This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence ( http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 17 June 2015
                : 17 June 2015
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                Editorial

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