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      Physiological Significance of Gastrointestinal Somatostatin

      Hormone Research in Paediatrics

      S. Karger AG

      Somatostatin, Stomach, Pancreas, Nutrient entry, Paracrine, Endocrine

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          Somatostatin participates in the regulation of nutrient entry from the intestinal tract into the circulation. Thus, dietary fats and proteins may elicit significant increases of gastropancreatic somatostatin. Regulation of postprandial somatostatin secretion may occur via neural, hormonal and humoral factors. This peptide, in pharmacological doses, inhibits virtually all gastrointestinal exo- and endocrine functions as well as local motor activity. Neutralization of endogenous circulating somatostatin with specific antiserum is followed by increases in GH and enteroglucagon, augmenting also the postprandial rise of gastrin, insulin and pancreatic polypeptide. Somatostatin deficiency can be observed in obese subjects with hyperinsulinism. Concomitant elevation of insulin and gastrin levels can be antagonized by exogenous somatostatin. These findings confirm the importance of somatostatin as a peripheral regulator in experimental and human biology.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          28 November 2008
          : 29
          : 2-3
          : 75-78
          Department of Internal Medicine II, Technical University of Munich, FRG
          180972 Horm Res 1988;29:75–78
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 4
          Somatostatin: Recent Advances in Basic Research and Clinical Applications


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