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Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases.
Henri Duboc
1 ,
Sylvie Rajca ,
Dominique Rainteau ,
David Benarous ,
Marie-Anne Maubert ,
Elodie Quervain ,
Ginette Thomas ,
Véronique Barbu ,
Lydie Humbert ,
Guillaume Despras ,
Chantal Bridonneau ,
Fabien Dumetz ,
Jean-Pierre Grill ,
Joëlle Masliah ,
Laurent Beaugerie ,
Jacques Cosnes ,
Olivier Chazouillères ,
Raoul Poupon ,
Claude Wolf ,
Jean-Maurice Mallet ,
Philippe Langella ,
Germain Trugnan ,
Harry Sokol ,
Philippe Seksik
Apr 2013
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Abstract
Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD-associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response.