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      Mechanisms of controlled drug release from drug-eluting stents.

      Advanced Drug Delivery Reviews
      Coronary Restenosis, etiology, prevention & control, Delayed-Action Preparations, therapeutic use, Humans, Stents, Treatment Outcome

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          Abstract

          The clinical importance of drug-eluting stents (DESs) has been demonstrated by their unparalleled success in preventing restenosis after stenting procedures. The magnitude of success is historic despite their short history. The current DESs deliver a single drug aiming to prevent or minimize proliferation of smooth muscle cells. Since the restenosis process involves several different biological responses, the ability to deliver the right drugs at the right times is critical for further development of the second generation of DESs. As the type of drugs that can be delivered from DESs varies, it is imperative to understand the drug delivery mechanisms and the approaches available for drug coating on the stents. The drug delivery mechanisms of current DESs that have been used clinically and under clinical trials are explained.

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          Author and article information

          Journal
          16546289
          10.1016/j.addr.2006.01.016

          Chemistry
          Coronary Restenosis,etiology,prevention & control,Delayed-Action Preparations,therapeutic use,Humans,Stents,Treatment Outcome

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