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      Cytokine control of memory T-cell development and survival.

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          Abstract

          Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate of the T cell. Members of the common cytokine-receptor gamma-chain (gammac)-cytokine family--in particular, interleukin-7 (IL-7) and IL-15--act at each stage of the immune response to promote proliferation and survival. In this manner, a stable and protective, long-lived memory CD8+ T-cell pool can be propagated and maintained.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1733
          1474-1733
          Apr 2003
          : 3
          : 4
          Affiliations
          [1 ] Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-1319, USA.
          Article
          nri1052
          10.1038/nri1052
          12669018
          723a5bff-8365-4a1f-aec8-37c9970a3784

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