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      Disparate Effects of Calmodulin Inhibitors on Corneal Epithelial Migration in Rabbit and Rat

      ,

      Ophthalmic Research

      S. Karger AG

      Actin, Corneal epithelial migration, Calmodulin, Trifluoperazine, Naphthalenesulfonamide

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          Abstract

          We investigated the effects of two calmodulin inhibitors, trifluoperazine and N-6-aminohexyl-5-chloro-l-naphthalenesulfonamide, on corneal epithelial wound closure in rabbits and rats. Measured, round epithelial defects were made on corneas by gentle scraping. After 20 h in organ culture with or without inhibitor, the remaining wound area was measured and samples were fixed for microscopy. In the rabbit, these inhibitors had little or no effect on the rate of wound coverage. In the rat, however, both trifluoperazine (3–40 μ M) and N-6-aminohexyl-5-chloro-l-naphthalenesulfonamide (10–100 μ M) inhibited wound closure in a dose-dependent manner. Thus we believe that calmodulin plays a crucial role in epithelial migration in the rat. In the rabbit, there seems to exist a mechanism that is not critically dependent upon an intact calmodulin pathway.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1985
          1985
          04 December 2009
          : 17
          : 1
          : 27-33
          Affiliations
          Department of Cornea Research, Eye Research Institute of Retina Foundation and Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Mass., USA
          Article
          265346 Ophthalmic Res 1985;17:27–33
          10.1159/000265346
          3982781
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

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