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      Photodegradable hydrogels for dynamic tuning of physical and chemical properties.

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          Abstract

          We report a strategy to create photodegradable poly(ethylene glycol)-based hydrogels through rapid polymerization of cytocompatible macromers for remote manipulation of gel properties in situ. Postgelation control of the gel properties was demonstrated to introduce temporal changes, creation of arbitrarily shaped features, and on-demand pendant functionality release. Channels photodegraded within a hydrogel containing encapsulated cells allow cell migration. Temporal variation of the biochemical gel composition was used to influence chondrogenic differentiation of encapsulated stem cells. Photodegradable gels that allow real-time manipulation of material properties or chemistry provide dynamic environments with the scope to answer fundamental questions about material regulation of live cell function and may affect an array of applications from design of drug delivery vehicles to tissue engineering systems.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          1095-9203
          0036-8075
          Apr 03 2009
          : 324
          : 5923
          Affiliations
          [1 ] Department of Chemical and Biological Engineering, University of Colorado, 424 UCB ECCH 111, Boulder, CO 80309, USA.
          Article
          324/5923/59 NIHMS140147
          10.1126/science.1169494
          2756032
          19342581

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