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      Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

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          Abstract

          The aim of this study is a present of a simple solvothermal synthesis approach to preparation of Cu-based magnetic metal organic framework (MMOF) and subsequently its application as sorbent for ultrasound assisted magnetic solid phase extraction (UAMSPE) of ampicillin (AMP) from cow milk samples prior to high performance liquid chromatography-Ultraviolet (HPLC-UV) determination. Characteristics of prepared MMOF were fully investigated by different techniques which showed the exclusive properties of proposed sorbent in terms of proper functionality, desirable magnetic property and also high specific surface area. Different influential factors on extraction recovery including sorbent dosage, ultrasonic time, washing solvent volume and eluent solvent volume were assessed using central composite design (CCD) based response surface methodology (RSM) as an operative and powerful optimization tool. This is the first report for determination of AMP using MMOF. The proposed method addressed some drawbacks of other methods and sorbents for determination of AMP. The presented method decreases the extraction time (4 min) and also enhances adsorption capacity (250 mg/g). Moreover, the magnetic property of presented sorbent (15 emu/g) accelerates the extraction process which does not need filtration, centrifuge and precipitation procedures. Under the optimized conditions, the proposed method is applicable for linear range of 1.0–5000.0 μg/L with detection limit of 0.29 μg/L, satisfactory recoveries (≥95.0%) and acceptable repeatability (RSD less than 4.0%). The present study indicates highly promising perspectives of MMOF for highly effective analysis of AMP in complicated matrices.

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          Highlights

          • MMOF was prepared and used for the first time for determination of ampicillin from cow milk samples.

          • The extraction method was convenient, rapid and the MMOF can be used more than 8 times.

          • The MMOF have high specific surface area (300.0 m 2/g) and high adsorption capacity (250.5 mg g −1).

          • The separation time was only 5 min, which was much shorter than other reported.

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          Most cited references 51

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          Reactive Adsorption of Ammonia on Cu-Based MOF/Graphene Composites

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            Adsorption behavior of metal–organic frameworks for methylene blue from aqueous solution

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              Determination of pKa values of active pharmaceutical ingredients

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                Author and article information

                Contributors
                Journal
                J Pharm Anal
                J Pharm Anal
                Journal of Pharmaceutical Analysis
                Xi'an Jiaotong University
                2095-1779
                2214-0883
                20 February 2020
                August 2020
                20 February 2020
                : 10
                : 4
                : 365-375
                Affiliations
                Chemistry Department, Yasouj University, Yasouj, 75918-74831, Iran
                Author notes
                []Corresponding author. m_ghaedi@ 123456mail.yu.ac.ir
                Article
                S2095-1779(19)30775-0
                10.1016/j.jpha.2020.02.006
                7474158
                © 2020 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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